1-Pyrrolidinamine

Base Information

• Chemical Name: 1-Pyrrolidinamine
• CAS No.: 16596-41-1
• Molecular Formula: C4H10N2
• Molecular Weight: 86.1368
• Hs Code.: 2933990090
• European Community (EC) Number: 630-631-2
• NSC Number: 80647
• UNII: DF424U7HM6
• DSSTox Substance ID: DTXSID40168052
• Nikkaji Number: J38.368F
• Wikidata: Q72441865
• Mol file: 16596-41-1.mol

Synonyms:1-Aminopyrrolidine;pyrrolidin-1-amine;16596-41-1;1-Pyrrolidinamine;N-Aminopyrrolidine;Pyrrolidine, 1-amino-;aminopyrrolidine;DF424U7HM6;NSC 80647;NSC-80647;pyrrolidin-1-ylamine;pyrrolidylamine;NSC80647;UNII-DF424U7HM6;DTXSID40168052;MFCD07368381;AKOS003582850;BB 0218179;FT-0601174;P2560;A26943;EN300-201007;F13227;A810683;J-524150

Chemical Property of 1-Pyrrolidinamine

Chemical Property:

• Vapor Pressure: 21.9mmHg at 25°C
• Refractive Index: 1.497
• Boiling Point: 112.26 °C at 760 mmHg
• PKA: 8.19±0.20(Predicted)
• Flash Point: 28.125 °C
• PSA: 29.26000
• Density: 0.986 g/cm³
• LogP: 1.39610
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 86.084398327
• Heavy Atom Count: 6
• Complexity: 38.8

Purity/Quality:

99% ^*data from raw suppliers

1-Aminopyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Nitrogen Compounds
• Canonical SMILES: C1CCN(C1)N

Technology Process of 1-Pyrrolidinamine

There total 14 articles about 1-Pyrrolidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.56%

→ N-aminopyrrolidine (16596-41-1)

Guidance literature:

Reference yield: 92.0%

N-nitrosopyrrolidine (930-55-2) → N-aminopyrrolidine (16596-41-1)

Guidance literature:

With carbon dioxide; water; ammonium chloride; zinc; at 35 ℃; for 1.5h; under 1500.15 Torr; Autoclave; Green chemistry;

DOI:10.1007/s10593-018-2349-0

Reference yield: 92.0%

2-pyrrolidin-1-ylbenzo[de]isoquinoline-1,3-dione → 2-amino-1H-benzo[de]isoquinoline-1,3(2H)-dione (5690-46-0) + N-aminopyrrolidine (16596-41-1)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1002/chem.202102593

upstream raw materials:

N-nitrosopyrrolidine

(E)-but-2-enoic acid

(Z)-but-2-enoic acid

1,4-dichlorobutane

Downstream raw materials:

3,3-diphenyl-1-pyrrolidino-azetidine-2,4-dione

2-Amino-N-pyrrolidin-1-yl-benzamide

4-Chloro-2-methylamino-N-pyrrolidin-1-yl-benzamide

[1-Phenyl-eth-(Z)-ylidene]-pyrrolidin-1-yl-amine

Refernces

• 1、 Dhenain,Darwich,Frangieh,Goutal,Delalu. "Synthesis of N-aminopyrrolidine by the raschig process: Kinetic and mechanistic study of the monochloramine-pyrrolidine interaction". . p. 338 - 349. Retrieved 2014.
• 2、 Manoj Kumar, Mesram,Venkataramana, Parikibanda,Yadagiri Swamy, Parikibanda,Chityala, Yadaiah. "N-Amino-1,8-Naphthalimide is a Regenerated Protecting Group for Selective Synthesis of Mono-N-Substituted Hydrazines and Hydrazides". supporting information. p. 17713 - 17721. Retrieved 2021/11/10.