Gloriosine

Base Information

• Chemical Name: Gloriosine
• CAS No.: 7411-12-3
• Molecular Formula: C21H23 N O6
• Molecular Weight: 385.417
• Hs Code.: 2924299090
• European Community (EC) Number: 630-568-0
• NSC Number: 403142
• UNII: U02803H7OJ
• DSSTox Substance ID: DTXSID80225057
• Nikkaji Number: J67.640C
• Wikidata: Q9268800
• Pharos Ligand ID: CKS17RNM1XMH
• Metabolomics Workbench ID: 143519
• ChEMBL ID: CHEMBL85710
• Mol file: 7411-12-3.mol

Synonyms:N-deacetyl-N-formylcolchicine

Chemical Property of Gloriosine

Chemical Property:

• Vapor Pressure: 2.45E-20mmHg at 25°C
• Melting Point: 264-267°C
• Boiling Point: 715.8°C at 760 mmHg
• PKA: 14.63±0.40(Predicted)
• Flash Point: 386.7°C
• PSA: 83.09000
• Density: 1.27g/cm³
• LogP: 3.50830
• Storage Temp.: -20?C Freezer, Under Inert Atmosphere
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 385.15253745
• Heavy Atom Count: 28
• Complexity: 697

Purity/Quality:

99%, ^*data from raw suppliers

N-Deacetyl-N-formylColchicine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C2C(=CC1=O)C(CCC3=CC(=C(C(=C32)OC)OC)OC)NC=O
• Isomeric SMILES: COC1=CC=C2C(=CC1=O)[C@H](CCC3=CC(=C(C(=C32)OC)OC)OC)NC=O
• Uses: Colchicine (C640000) derivative. A new alkaloid from Gloriosa superba.

Technology Process of Gloriosine

There total 3 articles about Gloriosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formic acid (64-18-6) + deacetylcolchicine (3476-50-4) → N-deacetyl-N-formylcolchicine (7411-12-3)

Guidance literature:

With pyridine;

DOI:10.1021/ja01111a521

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) → N-deacetyl-N-formylcolchicine (7411-12-3)

Guidance literature:

With methanol; diethyl ether;

DOI:10.1002/hlca.19500330629

Reference yield:

→ N-deacetyl-N-formylcolchicine (7411-12-3)

Guidance literature:

Alkaloid S(3) (Ie), Diazomethan;

upstream raw materials:

formic acid

deacetylcolchicine

diazomethane

Downstream raw materials:

7-desacetamido-7-oxocolchicine