3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer

Base Information

• Chemical Name: 3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer
• CAS No.: 26680-10-4
• Molecular Formula: C6H8O4
• Molecular Weight: 144.12532
• Mol file: 26680-10-4.mol

Synonyms:Poly(D,L-lactide);1,4-Dioxane-2,5-dione, 3,6-dimethyl-, homopolymer;26680-10-4;3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer;3,6-dimethyl-1,4-dioxane-2,5-dione;Poly(DL-lactide);Poly(L-lactide);Resomer R208;

Chemical Property of 3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer

Chemical Property:

• Melting Point: 215 °C
• Flash Point: 113°C
• PSA: 52.60000
• Density: 1.23 g/cm3
• LogP: -0.13660
• Storage Temp.: 2-8°C
• Solubility.: Soluble in dichloromethane, tetrahydrofuran, ethyl acetate, chloroform, hexafluoroisopropanol, and acetone. Insoluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

Poly(D,L-lactide) acid terminated, Mw 10,000-18,000 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Controlled release May be used to make drug delivery materials for controlled release.

Technology Process of 3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer

There total 109 articles about 3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.2%

D,L-lactide (95-96-5,26680-10-4,26969-66-4,615-95-2) → (3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione (13076-19-2,26680-10-4,26969-66-4,615-95-2)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; tris(pentafluorophenyl)borate; In toluene; at 20 ℃; for 10h;

Reference yield: 16.0%

acetylacetone (123-54-6,81235-32-7) → LACTIC ACID (849585-22-4,106989-11-1,26811-96-1,31587-11-8,26100-51-6) + 2-acetoxypropionic acid (535-17-1) + Ethylene glycol di-tert-butyl diether (26547-47-7) + 3-acetoxy-3-methylbutanoic acid (44983-17-7) + 2,5-hexanedione (110-13-4) + D,L-lactide (95-96-5,26680-10-4,26969-66-4,615-95-2)

Guidance literature:

With dihydrogen peroxide; In tert-butyl alcohol; for 36h; Reflux;

DOI:10.1007/s11172-013-0316-6

Reference yield: 4.0%

polylactic acid → (3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione (13076-19-2,26680-10-4,26969-66-4,615-95-2) + D,L-lactide (95-96-5,26680-10-4,26969-66-4,615-95-2)

Guidance literature:

tin(IV) butyltin tris(2-ethylhexanoate); In water; at 218 ℃; under 31 Torr;

upstream raw materials:

ethyl 2-hydroxypropionate

L-Lactic acid

D-Lactic acid

LACTIC ACID

Downstream raw materials:

1,1-diphenylpropane-1,2-diol

lactanilide

3,6-dimethyl-1,4-dioxane-2,5-dione

(S)-2-hydroxy-propionic acid (S)-1-benzyloxycarbonyl-ethyl ester

Refernces

• 1、 Zhu, Jian-Bo,Chen, Eugene Y.-X.. "From meso-Lactide to Isotactic Polylactide: Epimerization by B/N Lewis Pairs and Kinetic Resolution by Organic Catalysts". . p. 12506 - 12509. Retrieved 2015.
• 2、 Goudarzi, Fariba,Asadi, Asadollah,Afsharpour, Maryam,Jamadi, Robab Hassanvand. "In Vitro Characterization and Evaluation of the Cytotoxicity Effects of Nisin and Nisin-Loaded PLA-PEG-PLA Nanoparticles on Gastrointestinal (AGS and KYSE-30), Hepatic (HepG2) and Blood (K562) Cancer Cell Lines". . p. 1554 - 1566. Retrieved 2018.
• 3、 Akopyan,Khachatryan. "Synthesis of new substituted 2,3-dihydro-1,4-dioxin-2-ones and 1,4-dioxan-2-ones". . p. 1034 - 1036. Retrieved 2003.
• 4、 Dunn, Anna L.,Landis, Clark R.. "Progress toward reaction monitoring at variable temperatures: a new stopped-flow NMR probe design". . p. 329 - 336. Retrieved 2017.
• 5、 Upare, Pravin P.,Yoon, Ji Woong,Hwang, Dong Won,Lee, U-Hwang,Hwang, Young Kyu,Hong, Do-Young,Kim, Jin Chul,Lee, Jeong Hyeon,Kwak, Sang Kyu,Shin, Hyeyoung,Kim, Hyungjun,Chang, Jong-San. "Design of a heterogeneous catalytic process for the continuous and direct synthesis of lactide from lactic acid". . p. 5978 - 5983. Retrieved 2016.
• 6、 De Clercq, Rik,Makshina, Ekaterina,Sels, Bert F.,Dusselier, Michiel. "Catalytic Gas-Phase Cyclization of Glycolate Esters: A Novel Route Toward Glycolide-Based Bioplastics". . p. 5649 - 5655. Retrieved 2018.
• 7、 Hassanvand Jamadi, Robab,Asadi, Asadollah,Yaghoubi, Hashem,Goudarzi, Fariba. "Investigation into the Anticancer Activity and Apoptosis Induction of Brevinin-2R and Brevinin-2R-Conjugated PLA–PEG–PLA Nanoparticles and Strong Cell Cycle Arrest in AGS, HepG2 and KYSE-30 Cell Lines". . p. 1225 - 1239. Retrieved 2019.
• 8、 -. "Method for catalytically synthesizing lactide". Paragraph 0056-0076; 0081-0084; 0095-0096; 0099-0100. . Retrieved 2021/01/29.