Azosemide

Base Information

• Chemical Name: Azosemide
• CAS No.: 27589-33-9
• Molecular Formula: C12H11 Cl N6 O2 S2
• Molecular Weight: 370.843
• Hs Code.: 2935009090
• European Community (EC) Number: 248-549-7
• UNII: MR40VT1L8Z
• DSSTox Substance ID: DTXSID7046910
• Nikkaji Number: J10.727A
• Wikipedia: Azosemide
• Wikidata: Q4832859
• NCI Thesaurus Code: C77515
• Metabolomics Workbench ID: 49566
• ChEMBL ID: CHEMBL1097235
• Mol file: 27589-33-9.mol

Synonyms:2-chloro-5-(1H-tetrazol-5-yl)-N(sup 4)-2-thenylsulfanilamide;5-(4-chloro-5-sulfamyl-2-thienylaminophenyl)tetrazole;azosemid;azosemide;benzenesulfonamide, 2-chloro-5-(1H-tetrazol-5-yl)-4-((2-thienylmethyl)amino)-;BM 02.001;Ple 1053

Chemical Property of Azosemide

Chemical Property:

• Vapor Pressure: 7.19E-18mmHg at 25°C
• Melting Point: 218-221°
• Refractive Index: 1.6100 (estimate)
• Boiling Point: 671.1°Cat760mmHg
• PKA: 3.58±0.10(Predicted)
• Flash Point: 359.6°C
• PSA: 163.27000
• Density: 1.661g/cm³
• LogP: 3.69520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 370.0073437
• Heavy Atom Count: 23
• Complexity: 504

Purity/Quality:

Azosemide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=C1)CNC2=CC(=C(C=C2C3=NNN=N3)S(=O)(=O)N)Cl
• Recent ClinicalTrials: Comparison of Long- and Short-acting Diuretics in Congestive Heart Failure
• Recent NIPH Clinical Trials: The effect of low dose tolvaptan after cardiovascular surgery
• Description: Azosemide is a high-ceiling diuretic similiar in structure and profile to furosemide, albeit somewhat less potent and less bioavailable. It is useful in the treatment of congestive heart failure and similar edematous conditions.
• Uses: Diuretic. Azosemide is a high-ceiling diuretic agent. It is used in the treatment of edematous states and hypertension.
• Therapeutic Function: Diuretic

Technology Process of Azosemide

There total 1 articles about Azosemide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ azosemide (27589-33-9)

Guidance literature:

4-Chloro-5-sulfamoyl-2-thenylaminobenzonitrile, Na-azid u. NH4Cl;