Detail of "27589-33-9"

Reference

Clinical investigations on the pharmacology of azosemide (SK-110) in comparison with furosemide in healthy volunteers

Clinical investigations on the pharmacology of azosemide (SK-110) in comparison with furosemide in healthy volunteers. Kuzuya, F.; Sugino, N.; Yoshizumi, K.; Goto, U.; Oshima, K. (Sch. Med., Nagoya Univ., Nagoya, Japan). Int. J. Clin. Pharmacol., Ther. Toxicol., 22(6), 291-9 (English) 1984. CODEN: IJCPB5. ISSN: 0300-9718. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The diuretic action of azosemide (I) [27589-33-9] in healthy subjects was weaker than that of furosemide (II) [54-31-9]. With respect to 24-h diuresis, the same effect was obsd. with 60 mg I as with 40 mg II orally. The action of I, however, was longer lasting than that of II.

Hormonal response to acute diuresis - a comparative study of furosemide and azosemide

Hormonal response to acute diuresis - a comparative study of furosemide and azosemide. Ogawa, K.; Hatano, T.; Yamamoto, M.; Matsui, N. (Res. Inst. Environ. Med., Nagoya Univ., Nagoya 464, Japan). Int. J. Clin. Pharmacol., Ther. Toxicol., 22(6), 284-90 (English) 1984. CODEN: IJCPB5. ISSN: 0300-9718. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Oral administration of furosemide (I) [54-31-9] (40 mg) or azosemide (II) [27589-33-9] (60 mg) in healthy subjects increased urine vol., with peaks being obsd. at 1-2 and 2-3 h, resp. The slower diuretic action of II appeared assocd. with delayed hormonal responses, particularly with respect to urinary adrenaline [51-43-4] and noradrenaline [51-41-2] excretion, plasma renin [9015-94-5] activity, serum and urinary aldosterone [52-39-1], plasma antidiuretic hormone [11000-17-2], and serum prolactin [9002-62-4].