Technology Process of (2S,2S)-2-(2-chloro-3-nitrobenzylamino)-3-methylpentan-1-ol
There total 3 articles about (2S,2S)-2-(2-chloro-3-nitrobenzylamino)-3-methylpentan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - -30 °C
2: 3.29 g / NaCNBH3; HOAc / methanol / Heating
With
oxalyl dichloride; sodium cyanoborohydride; acetic acid; dimethyl sulfoxide; triethylamine;
In
methanol; dichloromethane;
1: Swern oxidation;
DOI:10.1021/jm0491492
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium borohydride; boron trifluoride etherate / tetrahydrofuran / 5 h / 20 °C
2: oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - -30 °C
3: 3.29 g / NaCNBH3; HOAc / methanol / Heating
With
sodium tetrahydroborate; oxalyl dichloride; boron trifluoride diethyl etherate; sodium cyanoborohydride; acetic acid; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane;
2: Swern oxidation;
DOI:10.1021/jm0491492
- Guidance literature:
-
With
sodium cyanoborohydride; acetic acid;
In
methanol;
Heating;
DOI:10.1021/jm0491492