3-Methoxy-4-(benzyloxy)phenethylamine Hydrochloride

Base Information

• Chemical Name: 3-Methoxy-4-(benzyloxy)phenethylamine Hydrochloride
• CAS No.: 1860-57-7
• Molecular Formula: C16H19 N O2 . Cl H
• Molecular Weight: 293.793
• Hs Code.: 2923900090
• Mol file: 1860-57-7.mol

Synonyms:Benzeneethanamine,3-methoxy-4-(phenylmethoxy)-, hydrochloride (9CI); Phenethylamine,4-(benzyloxy)-3-methoxy-, hydrochloride (6CI,7CI,8CI);2-[4-(Benzyloxy)-3-methoxyphenyl]ethanamine hydrochloride;4-Benzyloxy-3-methoxyphenethylamine hydrochloride

Chemical Property of 3-Methoxy-4-(benzyloxy)phenethylamine Hydrochloride

Chemical Property:

• Vapor Pressure: 1.88E-06mmHg at 25°C
• Melting Point: 175-177°C
• Boiling Point: 395.1°Cat760mmHg
• Flash Point: 212.5°C
• PSA: 44.48000
• Density: g/cm³
• LogP: 4.27770
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Methoxy-4-(benzyloxy)phenethylamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A phenylethylamine derivative with radioprotective and pharmacological properties A phenylethylamine derivative with radioprotective and pharmacological properties.

Technology Process of 3-Methoxy-4-(benzyloxy)phenethylamine Hydrochloride

There total 11 articles about 3-Methoxy-4-(benzyloxy)phenethylamine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-methoxy-4-benzyloxy-ω-nitrostyrolene (63909-38-6,1860-56-6) → [2-(4-benzyloxy-3-methoxyphenyl)ethyl]amine hydrochloride (1860-57-7)

Guidance literature:

3-methoxy-4-benzyloxy-ω-nitrostyrolene; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2.5h; Reflux;

With water; In tetrahydrofuran; at 0 ℃;

With hydrogenchloride; In diethyl ether;

DOI:10.1016/j.bmc.2012.05.057

Reference yield: 64.0%

3-Methoxy-4-benzyloxy-N-tert.-butyloxycarbonyl-phenaethylamin (23428-81-1) → [2-(4-benzyloxy-3-methoxyphenyl)ethyl]amine hydrochloride (1860-57-7)

Guidance literature:

3-Methoxy-4-benzyloxy-N-tert.-butyloxycarbonyl-phenaethylamin; With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.666667h;

With sodium hydrogencarbonate; In dichloromethane; water; Cooling with ice;

With hydrogenchloride; In diethyl ether;

Reference yield:

2-[4-(benzyloxy)-3-methoxyphenyl]ethylamine (22231-61-4) → [2-(4-benzyloxy-3-methoxyphenyl)ethyl]amine hydrochloride (1860-57-7)

Guidance literature:

With hydrogenchloride; In diethyl ether;

upstream raw materials:

2-(4-(benzyloxy)-3-methoxyphenyl)acetonitrile

3-methoxy-4-(phenylmethoxy)benzaldehyde

4-benzyloxy-3-methoxybenzyl alcohol

1-(benzyloxy)-4-(chloromethyl)-2-methoxybenzene

Downstream raw materials:

1-(4-(benzyloxy)-3-methoxyphenethyl)-4-(3-phenylpropyl)piperazine

N-[2-(4-benzyloxy-3-methoxyphenyl)ethyl]propionamide

N-(2-(4-(benzyloxy)-3-methoxyphenyl)ethyl)-2-(3-methoxyphenyl)acetamide

(S)-2-benzyloxy-3,11-dimethoxy-5,8,13,13a-tetrahydro-6H-dibenzo[a,g]quinolizine

Refernces

• 1、 -. "1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES HAVING EFFECTS OF PREVENTING AND TREATING DEGENERATIVE AND INFLAMMATORY DISEASES". Page/Page column 6. . Retrieved 2010/09/05.
• 2、 Nasreen, Amber,Gundlach, Heidrun,Zenk, Meinhart H.. "Incorporation of phenethylisoquinolines into colchicine in isolated seeds of Colchicum autumnale". . p. 107 - 115. Retrieved 2007/10/03.