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CAS No.: | 1860-57-7 |
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Name: | 3-Methoxy-4-(benzyloxy)phenethylamine Hydrochloride |
Article Data: | 4 |
Molecular Structure: | |
Formula: | C16H19 N O2 . Cl H |
Molecular Weight: | 293.793 |
Synonyms: | Benzeneethanamine,3-methoxy-4-(phenylmethoxy)-, hydrochloride (9CI); Phenethylamine,4-(benzyloxy)-3-methoxy-, hydrochloride (6CI,7CI,8CI);2-[4-(Benzyloxy)-3-methoxyphenyl]ethanamine hydrochloride;4-Benzyloxy-3-methoxyphenethylamine hydrochloride |
Density: | g/cm3 |
Melting Point: | 175-177°C |
Boiling Point: | 395.1°Cat760mmHg |
Flash Point: | 212.5°C |
PSA: | 44.48000 |
LogP: | 4.27770 |
3-methoxy-4-benzyloxy-ω-nitrostyrolene
[2-(4-benzyloxy-3-methoxyphenyl)ethyl]amine hydrochloride
Conditions | Yield |
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Stage #1: 3-methoxy-4-benzyloxy-ω-nitrostyrolene With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 2.5h; Reflux; Stage #2: With water In tetrahydrofuran at 0℃; Stage #3: With hydrogenchloride In diethyl ether | 75% |
3-Methoxy-4-benzyloxy-N-tert.-butyloxycarbonyl-phenaethylamin
[2-(4-benzyloxy-3-methoxyphenyl)ethyl]amine hydrochloride
Conditions | Yield |
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Stage #1: 3-Methoxy-4-benzyloxy-N-tert.-butyloxycarbonyl-phenaethylamin With trifluoroacetic acid In dichloromethane at 0℃; for 0.666667h; Stage #2: With sodium hydrogencarbonate In dichloromethane; water Cooling with ice; Stage #3: With hydrogenchloride In diethyl ether | 64% |
Multi-step reaction with 2 steps 1: trifluoroacetic acid / dichloromethane / 0.67 h / 0 °C 2: hydrogenchloride / diethyl ether View Scheme |
2-(4-(benzyloxy)-3-methoxyphenyl)acetonitrile
[2-(4-benzyloxy-3-methoxyphenyl)ethyl]amine hydrochloride
Conditions | Yield |
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With hydrogenchloride; sodium tetrahydroborate; cobalt(II) chloride 1.) MeOH, 20 deg C, 1 h; Multistep reaction; |
3-methoxy-4-(phenylmethoxy)benzaldehyde
[2-(4-benzyloxy-3-methoxyphenyl)ethyl]amine hydrochloride
Conditions | Yield |
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Multi-step reaction with 4 steps 1: 96.6 percent / NaBH4 / methanol / 3 h 2: 93.5 percent / thionyl chloride / diethyl ether / 6 h 3: dimethylformamide / 168 h / Ambient temperature 4: 1.) cobaltous chloride hexahydrate, NaBH4, 2.) 3 N HCl / 1.) MeOH, 20 deg C, 1 h View Scheme | |
Multi-step reaction with 2 steps 1.1: ammonium acetate; acetic acid / 4 h / 90 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 0 °C / Reflux 2.2: 0 °C View Scheme |
4-benzyloxy-3-methoxybenzyl alcohol
[2-(4-benzyloxy-3-methoxyphenyl)ethyl]amine hydrochloride
Conditions | Yield |
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Multi-step reaction with 3 steps 1: 93.5 percent / thionyl chloride / diethyl ether / 6 h 2: dimethylformamide / 168 h / Ambient temperature 3: 1.) cobaltous chloride hexahydrate, NaBH4, 2.) 3 N HCl / 1.) MeOH, 20 deg C, 1 h View Scheme |
1-(benzyloxy)-4-(chloromethyl)-2-methoxybenzene
[2-(4-benzyloxy-3-methoxyphenyl)ethyl]amine hydrochloride
Conditions | Yield |
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Multi-step reaction with 2 steps 1: dimethylformamide / 168 h / Ambient temperature 2: 1.) cobaltous chloride hexahydrate, NaBH4, 2.) 3 N HCl / 1.) MeOH, 20 deg C, 1 h View Scheme |
2-[4-(benzyloxy)-3-methoxyphenyl]ethylamine
[2-(4-benzyloxy-3-methoxyphenyl)ethyl]amine hydrochloride
Conditions | Yield |
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With hydrogenchloride In diethyl ether |
Conditions | Yield |
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Multi-step reaction with 3 steps 1.1: potassium carbonate / acetone / 2 h / Reflux 2.1: ammonium acetate; acetic acid / 4 h / 90 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 0 °C / Reflux 3.2: 0 °C View Scheme |
Conditions | Yield |
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Multi-step reaction with 3 steps 1.1: potassium carbonate / acetone / 2 h / Reflux 2.1: ammonium acetate; acetic acid / 4 h / 90 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 0 °C / Reflux 3.2: 0 °C View Scheme |
Conditions | Yield |
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Multi-step reaction with 4 steps 1: triethylamine / chloroform / 24 h / 20 °C 2: potassium carbonate / acetone / 12 h / Heating / reflux 3: trifluoroacetic acid / dichloromethane / 0.67 h / 0 °C 4: hydrogenchloride / diethyl ether View Scheme |