Gold disodium thiomalate

Base Information

• Chemical Name: Gold disodium thiomalate
• CAS No.: 12244-57-4
• Molecular Formula: Au*C₄H₄O₄S*Na
• Molecular Weight: 368.096
• Hs Code.: 2930909090
• European Community (EC) Number: 235-479-7,623-247-1
• UNII: HRS6S09A0H
• DSSTox Substance ID: DTXSID80872500
• Nikkaji Number: J1.168.033J
• Wikipedia: Sodium_aurothiomalate,Disodium_aurothiomalate
• NCI Thesaurus Code: C74037
• Mol file: 12244-57-4.mol

Synonyms:Aurolate;Aurothiomalate;Aurothiomalate, Sodium;Gold Disodium Thiomalate, Monohydrate;Gold Sodium Thiomalate;Gold Thiomalate;Gold Thiomalate, Sodium;Gold Thiomalic Acid;Mercaptobutanedioic Acid Monogold(1+) Sodium Salt;Miocrin;Miocrisin;Monogold (1+) Disodium Thiomalate;Myochrysine;Myocrisin;Myocrysine;Sodium Aurothiomalate;Sodium Gold Thiomalate;Sodium Thiomalate, Gold;Sodium Thiomalatoaurate;Tauredon;Thiomalate, Gold;Thiomalatoaurate, Sodium

Chemical Property of Gold disodium thiomalate

Chemical Property:

• PSA: 105.56000
• LogP: -2.56010
• Water Solubility.: Very soluble in water. Practically insoluble in alcohol, ether
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 389.921313
• Heavy Atom Count: 12
• Complexity: 122

Purity/Quality:

98% ^*data from raw suppliers

Sodium Aurothiomalate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22-43
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(C(C(=O)[O-])[S-])C(=O)[O-].[Na+].[Na+].[Au+]
• Recent ClinicalTrials: Sirolimus and Gold Sodium Thiomalate in Treating Patients With Advanced Squamous Non-Small Cell Lung Cancer
• Physical properties: White to yellowish white powder; odorless; metallic taste; highly soluble in water; practically insoluble in ethanol and ether.
• Uses: Medicine (antirheumatic). Sodium aurothiomalate(I) is useful for high mobility group box chromosomal protein 1 western blotting.
• Clinical Use: Active progressive rheumatoid arthritis in adults
• Drug interactions: Potentially hazardous interactions with other drugs ACE-inhibitors: flushing and hypotension reported in combination. Penicillamine: increased risk of toxicity - avoid.

Technology Process of Gold disodium thiomalate

There total 1 articles about Gold disodium thiomalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

DL-thiomalic acid (70-49-5,644-87-1) + sodium tetrachloroaurate(III) (15189-51-2) → sodium gold(I) thiomalate (12244-57-4,42722-04-3,74916-57-7,119103-20-7)

Guidance literature:

In water; aq. soln. of sodium tetrachloroaurate was added to a stirred aq. soln. of the ligand; the ppt. was washed with water and ethanol, then dried;

DOI:10.1039/DT9800000767

upstream raw materials:

DL-thiomalic acid

sodium tetrachloroaurate(III)

Refernces