CAS No.12244-57-4,Sodium aurothiomalate Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	12244-57-4
Name:	Sodium aurothiomalate
Article Data:	1

Formula:	C4H6 O4 S . Au . x Na
Molecular Weight:	368.096
Synonyms:	Butanedioicacid, mercapto-, monogold(1+) sodium salt (9CI);Aurolate;Aurothiomalate sodium;Chrysothios;Gold sodium thiomalate;Kidon;Miocrisina;Myochrysin;Myochrysine;Myocrisin;Shiosol;Sodium aurithiomalate;Sodium aurothiomalate;Tauredon;
EINECS:	235-479-7
Solubility:	Very soluble in water. Practically insoluble in alcohol, ether
Hazard Symbols:
Risk Codes:	R20/21/22;R43
Safety:	Poison by subcutaneous and intramuscular routes. Moderately toxic by intravenous route. Human systemic effects: aggression, agranulocytosis, aplastic anemia, cell count changes, changes in circulation, cholestatic jaundice, dermatitis, encephalitis, fasciculations, flaccid paralysis without anesthesia, hemorrhage, hepatitis (hepatocellular necrosis), increased body temperature, interstitial fibrosis, muscle weakness, proteinuria, recording from peripheral motor nerve, depressed renal function tests, somnolence, structural changes in nerve sheath, thrombocytopenia, uncharacterized allergic reaction, changes in blood, teeth, and supporting structures. Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic Na₂O and SO_x.
PSA:	105.56000
LogP:	-2.56010

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Chemistry

IUPAC Name: Disodium; gold(1+); 2-sulfidobutanedioate
CAS: 12244-57-4
Formula: C₄H₃AuNa₂O₄S
Molecular Weight: 390.08
The Molecular Structure of Disodium; gold(1+); 2-sulfidobutanedioate (CAS NO.12244-57-4):

Flash Point: 108.8 °C
Enthalpy of Vaporization: 54.37 kJ/mol
Boiling Point: 256.3 °C at 760 mmHg
Vapour Pressure: 0.00475 mmHg at 25°C
Product Categories: organic-metal salt.

Toxicity Data With Reference

1.	orl-man TDLo:5500 µg/kg:PNS,KID,BLD	ARHEAW Arthritis and Rheumatism. 19 (1976),936.
2.	ims-wmn TDLo:182 µg/kg:SKN	BMJOAE British Medical Journal. 2 (1976),1294.
3.	ivn-wmn TDLo:2700 µg/kg/4W-I:CNS	JRHUA9 Journal of Rheumatology. 11 (1984),235.
4.	ims-wmn TDLo:20 mg/kg/1Y:CNS,KID	ARPAAQ Archives of Pathology. 96 (1973),133.
5.	ims-man TDLo:5 mg/kg/13W:BLD,MSK	JAMAAP JAMA, Journal of the American Medical Association. 133 (1947),754.
6.	ims-wmn LDLo:600 µg/kg/1W-I:PUL,SYS	JRSMD9 Journal of the Royal Society of Medicine. 77 (1984),960.
7.	par-wmn TDLo:3366 µg/kg/2W:CNS,PNS	NEURAI Neurology. 20 (1970),455.
8.	par-man TDLo:12,500 µg/kg/7W-I:CNS,PNS	JRHUA9 Journal of Rheumatology. 11 (1984),233.
9.	par-man TDLo:7857 µg/kg/11W-I:SKN	BMJOAE British Medical Journal. 286 (1983),1547.
10.	unr-cld TDLo:11,900 µg/kg/18W-I:	JRHUA9 Journal of Rheumatology. 13 (1986),224.

Safety Profile

Poison by subcutaneous and intramuscular routes. Moderately toxic by intravenous route. Human systemic effects: aggression, agranulocytosis, aplastic anemia, cell count changes, changes in circulation, cholestatic jaundice, dermatitis, encephalitis, fasciculations, flaccid paralysis without anesthesia, hemorrhage, hepatitis (hepatocellular necrosis), increased body temperature, interstitial fibrosis, muscle weakness, proteinuria, recording from peripheral motor nerve, depressed renal function tests, somnolence, structural changes in nerve sheath, thrombocytopenia, uncharacterized allergic reaction, changes in blood, teeth, and supporting structures. Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic Na₂O and SO_x.
Safety Information about Disodium; gold(1+); 2-sulfidobutanedioate (CAS NO.12244-57-4):
Hazard Codes:
Xn:
Risk Statements about Disodium; gold(1+); 2-sulfidobutanedioate (CAS NO.12244-57-4):
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R43: May cause sensitization by skin contact.
Safety Statements about Disodium; gold(1+); 2-sulfidobutanedioate (CAS NO.12244-57-4):
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS: MD5435000

Specification

Disodium ; gold(1+) ; 2-sulfidobutanedioate with CAS number of 12244-57-4 is also known as ((1,2-Dicarboxyethyl)thio)golddisodiumsalt ; ((1,2-Dicarboxyethyl)thio)-goldisodiumsalt ; (dihydrogenmercaptosuccinato)golddisodiumsalt ; (Mercaptobutanedioato(1-))golddisodiumsalt ; Aurothiomaleatesodium ; Autm ; chrysothios ; disodiumaurothiomalate . It can be used for anti-inflammatory analgesic .