Levamfetamine

Base Information

• Chemical Name: Levamfetamine
• CAS No.: 156-34-3
• Molecular Formula: C9H13N
• Molecular Weight: 135.209
• European Community (EC) Number: 205-850-8
• UNII: R87US8P740
• DSSTox Substance ID: DTXSID20166016
• Nikkaji Number: J9.368H
• Wikipedia: Levoamphetamine
• Wikidata: Q2506823
• NCI Thesaurus Code: C170114
• Pharos Ligand ID: HCA1DPGV1NQ2
• Metabolomics Workbench ID: 41852
• ChEMBL ID: CHEMBL19393
• Mol file: 156-34-3.mol

Synonyms:Amfetamine;Amphetamine;Amphetamine Sulfate;Amphetamine Sulfate (2:1);Centramina;Desoxynorephedrin;Fenamine;l Amphetamine;l-Amphetamine;levo Amphetamine;levo-Amphetamine;Levoamphetamine;Mydrial;Phenamine;Phenopromin;Sulfate, Amphetamine;Thyramine

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Levamfetamine

Chemical Property:

• Vapor Pressure: 0.307mmHg at 25°C
• Refractive Index: 1.527
• Boiling Point: 201.5 °C at 760 mmHg
• PKA: 9.94±0.10(Predicted)
• Flash Point: 87.4 °C
• PSA: 26.02000
• Density: 0.946 g/cm³
• LogP: 2.27660
• Storage Temp.: ?20°C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 135.104799419
• Heavy Atom Count: 10
• Complexity: 84.7

Purity/Quality:

Safty Information:

• Pictogram(s): F,T
• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25-24/25
• Safety Statements: 16-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=CC=C1)N
• Isomeric SMILES: C[C@H](CC1=CC=CC=C1)N
• Recent ClinicalTrials: A Study of C105 on Cognitive Dysfunction in Persons With Multiple Sclerosis
• Uses: CNS stimulant; anorexic. Controlled substance (stimulant)

Technology Process of Levamfetamine

There total 183 articles about Levamfetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methyl-5-phenyl-2-oxazolidinone (54418-69-8) → 2-amino-1-phenylpropane (60-15-1,156-34-3,51-64-9,300-62-9,17108-96-2,96332-84-2)

Guidance literature:

With 5% Pd(II)/C(eggshell); hydrogen; In tetrahydrofuran; at 20 ℃; for 3h; under 1 Torr;

DOI:10.1080/00397910903097302

Reference yield: 96.0%

2-methyl-3-phenylaziridine → 2-amino-1-phenylpropane (60-15-1,156-34-3,51-64-9,300-62-9,17108-96-2,96332-84-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 16h; under 760.051 Torr; Inert atmosphere;

Reference yield: 91.0%

(2-nitroprop-1-enyl)benzene (705-60-2) → 2-amino-1-phenylpropane (60-15-1,156-34-3,51-64-9,300-62-9,17108-96-2,96332-84-2)

Guidance literature:

With sodium tetrahydroborate; borane-THF; In tetrahydrofuran; at 25 ℃; for 144h;

DOI:10.1016/S0040-4020(01)89059-1

upstream raw materials:

(E)-2-(hydroxyimino)-1-phenylpropan-1-one

l-amphetamine

(1-phenylpropan-2-ylidene)hydrazine

2-methyl-2-phenylpropionamide

Downstream raw materials:

(R)-2-(4-chlorophenoxy)propanoic acid

bis-(2-hydroxy-ethyl)-(1-methyl-2-phenyl-ethyl)-amine

2-(1-methyl-2-phenyl-ethylamino)-ethanol

N-(1-Methyl-2-phenyl-ethyl)-β-mercapto-ethylamin

Refernces

• 1、 Granander, Johan,Sott, Richard,Hilmersson, Goeran. "Correlation between the6Li,15N coupling constant and the coordination number at lithium". . p. 4191 - 4197. Retrieved 2006.
• 2、 Haak, Edgar,Siebeneicher, Holger,Doye, Sven. "An ammonia equivalent for the dimethyltitanocene-catalyzed intermolecular hydroamination of alkynes". . p. 1935 - 1937. Retrieved 2000.
• 3、 Mori,Ishiyama,Akita,Suzuki,Mitsuoka,Oishi. "Reduction of nitroolefin using microorganisms". . p. 3449 - 3451. Retrieved 1990.
• 4、 Basso, Ernani A.,Fernandes, Cleverton de S.,Francisco, Camila B.,Gauze, Gisele de F.,Rittner, Roberto. "Rapid Synthesis of Primary Amines from Ketones using Choline Chloride/Urea Deep Eutectic as a Reaction Medium". . . Retrieved 2021/12/29.
• 5、 Du, Yi-Dan,Chen, Bi-Hong,Shu, Wei. "Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination". supporting information. p. 9875 - 9880. Retrieved 2021/03/29.