Technology Process of 5-chloro-2-ethyl-3-[ethyl(oxan-4-yl)amino]benzoic acid
There total 10 articles about 5-chloro-2-ethyl-3-[ethyl(oxan-4-yl)amino]benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 5-chloro-2-ethyl-3-[ethyl(oxan-4-yl)amino]benzoate;
With
sodium hydroxide;
In
tetrahydrofuran; methanol;
at 50 ℃;
for 48h;
With
hydrogenchloride;
In
tetrahydrofuran; methanol; water;
pH=2 - 3;
- Guidance literature:
-
C18H26ClNO2; C19H28ClNO2;
With
water; sodium hydroxide;
In
tetrahydrofuran;
at 50 ℃;
for 27h;
With
methanol;
In
tetrahydrofuran;
at 50 ℃;
for 21h;
With
hydrogenchloride;
In
tetrahydrofuran; water;
pH=2 - 3;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium carbonate / methanol / 1 h / 20 °C
2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 20 °C
3.1: nitric acid; sulfuric acid / methanol / 1.25 h / -5 - 0 °C / Cooling with ethanol-ice
3.2: 6 h / 0 °C / Inert atmosphere; Reflux
4.1: ammonium chloride; iron / water; methanol / 2.5 h / 20 - 70 °C
5.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / 20 °C / Inert atmosphere
5.2: 20 h / 20 °C
6.1: acetic acid / 1,1-dichloroethane / 0.08 h / 20 °C / Inert atmosphere
6.2: 26 h / 20 °C
7.1: sodium hydroxide; water / tetrahydrofuran / 27 h / 50 °C
7.2: 21 h / 50 °C
7.3: pH 2 - 3
With
sulfuric acid; water; hydrogen; nitric acid; iron; potassium carbonate; ammonium chloride; acetic acid; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; 1,1-dichloroethane; water; ethyl acetate; 1,2-dichloro-ethane;