N-(Trifluoroacetyl)glycine

Base Information

• Chemical Name: N-(Trifluoroacetyl)glycine
• CAS No.: 383-70-0
• Molecular Formula: C4H4F3NO3
• Molecular Weight: 171.076
• Hs Code.: 2924199090
• Mol file: 383-70-0.mol

Synonyms:Glycine,N-(trifluoroacetyl)- (6CI,7CI,8CI,9CI);N-(Trifluoroacetyl)glycine;NSC 306126;Trifluoroacetylglycine;

Chemical Property of N-(Trifluoroacetyl)glycine

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 0.000479mmHg at 25°C
• Melting Point: 120-121 °C
• Refractive Index: 1.386
• Boiling Point: 291.6 °C at 760 mmHg
• PKA: 2.99±0.10(Predicted)
• Flash Point: 130.2 °C
• PSA: 66.40000
• Density: 1.534 g/cm³
• LogP: 0.14040
• Storage Temp.: 2-8°C
• Solubility.: Chloroform, DMSO

Purity/Quality:

99% ^*data from raw suppliers

N-Trifluoroacetylglycine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: N-Trifluoroacetylglycine (cas# 383-70-0) is a compound useful in organic synthesis.

Technology Process of N-(Trifluoroacetyl)glycine

There total 9 articles about N-(Trifluoroacetyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

glycine (56-40-6,18875-39-3,25718-94-9) + trifluoroacetic anhydride (407-25-0) → TFA-Gly (383-70-0)

Guidance literature:

In tetrahydrofuran; from 0 deg C up to r.t. over 45 min;

DOI:10.1039/P19850001355

Reference yield: 95.0%

ethyl trifluoroacetate, (383-63-1) + glycine (56-40-6,18875-39-3,25718-94-9) → TFA-Gly (383-70-0)

Guidance literature:

glycine; With triethylamine; In methanol; for 0.0833333h;

ethyl trifluoroacetate,; In methanol; at 20 ℃; for 16h;

Reference yield: 93.2%

trifluoroacetic acid-methyl ester (431-47-0) + glycine (56-40-6,18875-39-3,25718-94-9) → TFA-Gly (383-70-0)

Guidance literature:

With sodium; In methanol; for 16h;

upstream raw materials:

S-ethyl trifluoroacetate

glycine

phenyl trifluoroacetate

trifluoroacetic anhydride

Downstream raw materials:

N-trifluoroacetylglycine vinyl ester

[(2-{Benzyl-[2-(2,2,2-trifluoro-acetylamino)-acetyl]-amino}-2-phenyl-acetylamino)-methyl]-phosphonic acid diethyl ester

[(2-{Benzyl-[2-(2,2,2-trifluoro-acetylamino)-acetyl]-amino}-3-methyl-butyrylamino)-methyl]-phosphonic acid diethyl ester

2-(2,2,2-trifluoroacetamido)acetic acid succinimidyl ester

Refernces

• 1、 Reuter, Cedric,Kleczka, Margarethe,De Mazancourt, Sarah,Neudoerfl, Joerg-Martin,Kuehne, Ronald,Schmalz, Hans-Guenther. "Stereoselective synthesis of proline-derived dipeptide scaffolds (prom-3 and prom-7) rigidified in a PPII helix conformation". . p. 2664 - 2667. Retrieved 2014.
• 2、 Fu, Jiping,Becker, Christopher,Cao, Li,Capparelli, Michael,Denay, Regis,Fujimoto, Roger,Gai, Yu,Gao, Zhaobo,Guenat, Christian,Karur, Subramanian,Kim, Hongyong,Li, Weikuan,Li, Xiaolin,Li, Wei,Lochmann, Thomas,Lu, Amy,Lu, Peichao,Luneau, Alexandre,Meier, Nicole,Mergo, Wosenu,Ng, Simon,Parker, David,Peng, Yunshan,Riss, Bernard,Rivkin, Alexey,Roggo, Silvio,Schroeder, Harald,Schuerch, Friedrich,Simmons, Robert L.,Sun, Feng,Sweeney, Zachary K.,Tjandra, Meiliana,Wang, Michael,Wang, Ruidong,Weiss, Andrew H.,Wenger, Nicolas,Wu, Quanbing,Xiong, Xin,Xu, Su,Xu, Wenjian,Yifru, Aregahegn,Zhao, Jibin,Zhou, Jianguang,Zürcher, Christian,Gallou, Fabrice. "Development of a cyclosporin A derivative with excellent anti-hepatitis C virus potency". . p. 957 - 969. Retrieved 2018.