C₁₄H₁₄FNO

Base Information

• Chemical Name: C₁₄H₁₄FNO
• CAS No.: 1428865-27-3
• Molecular Formula: C₁₄H₁₄FNO
• Molecular Weight: 231.27
• Mol file: 1428865-27-3.mol

Synonyms:C₁₄H₁₄FNO

Chemical Property of C₁₄H₁₄FNO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₁₄FNO

There total 4 articles about C₁₄H₁₄FNO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H14FNO2 (1428865-15-9) → C14H14FNO (1428865-27-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1021/ol400371h

Reference yield:

3-fluoro-2-iodobenzoic acid (387-48-4) → C14H14FNO (1428865-27-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: copper diacetate; sodium acetate / water / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / Cooling with ice

2.2: 2 h / 80 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

With lithium aluminium tetrahydride; copper diacetate; sodium acetate; sodium hydride; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1021/ol400371h

Reference yield:

aniline (62-53-3) → C14H14FNO (1428865-27-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: copper diacetate; sodium acetate / water / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / Cooling with ice

2.2: 2 h / 80 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

With lithium aluminium tetrahydride; copper diacetate; sodium acetate; sodium hydride; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1021/ol400371h

upstream raw materials:

3-fluoro-2-iodobenzoic acid

aniline

C₁₅H₁₄FNO₂

Downstream raw materials:

C₁₄H₁₂FNO

Refernces