3,5-dichlorobenzyl carbonochloridate

Base Information

• Chemical Name: 3,5-dichlorobenzyl carbonochloridate
• CAS No.: 1175526-48-3
• Molecular Formula: C₈H₅Cl₃O₂
• Molecular Weight: 239.485
• Mol file: 1175526-48-3.mol

Synonyms:3,5-dichlorobenzyl carbonochloridate

Chemical Property of 3,5-dichlorobenzyl carbonochloridate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-dichlorobenzyl carbonochloridate

There total 1 articles about 3,5-dichlorobenzyl carbonochloridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phosgene (75-44-5) + 3,5-dichlorobenzyl alcohol (60211-57-6) → 3,5-dichlorobenzyl carbonochloridate (1175526-48-3)

Guidance literature:

In dichloromethane; toluene; at 20 ℃; for 0.5h;

Reference yield: 100.0%

3,5-dichlorobenzyl carbonochloridate (1175526-48-3) + tert-butyl 2-(piperidin-4-yl)ethylcarbamate (165528-81-4) → 3,5-dichlorobenzyl 4-(2-((tert-butoxycarbonyl)amino)ethyl)piperidine-1-carboxylate (1613512-87-0)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2018.05.030

Reference yield: 94.0%

3,5-dichlorobenzyl carbonochloridate (1175526-48-3) + (piperidin-4-yl)carbamic acid tert-butyl ester (73874-95-0) → 3,5-dichlorobenzyl-4-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate (1246639-94-0)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2018.05.030

upstream raw materials:

phosgene

3,5-dichlorobenzyl alcohol

Downstream raw materials:

(2'-{[(3,5-Dichloro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester

C₂₉H₂₈Cl₂F₃NO₅

(2'-{[(3,5-Dichloro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid

3,5-Dichlorobenzyl 2-(2-((tert-butoxycarbonyl)amino)ethyl)morpholine-4-carboxylate

Refernces

• 1、 Scott, Jill M.,Baccei, Christopher,Bain, Gretchen,Broadhead, Alex,Evans, Jilly F.,Fagan, Patrick,Hutchinson, John H.,King, Christopher,Lorrain, Daniel S.,Lee, Catherine,Prasit, Peppi,Prodanovich, Pat,Santini, Angelina,Santini, Brian A.. "Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis". scheme or table. p. 6608 - 6612. Retrieved 2011/12/04.