Pyrogastrone

Base Information

• Chemical Name: Pyrogastrone
• CAS No.: 7421-40-1
• Molecular Formula: C34H50 O7 . 2 Na
• Molecular Weight: 614.80
• European Community (EC) Number: 231-044-0
• NCI Thesaurus Code: C82597
• Mol file: 7421-40-1.mol

Synonyms:CARBENOXOLONE SODIUM;Gastrausil;Pyrogastrone;Berkobiogastrone;Terulcon tabletten;Carbenoxolon dinatrium;Carbenoxolon-dinatrium;Carbenoxolone disodium;Carbenoxolone, disodium salt;Disodium glycyrrhetinyl succina;Carbenoxolone sodium [USAN:JAN];EINECS 231-044-0;Glycyrrhetinic acid hydrogen succinate, disodium salt;18-beta-Glycyrrhetinic acid hydrogen succinate, disodium salt;Sodium 3-beta-hydroxy-11-oxo-12-oleanen-30-oate sodium succinate;SCHEMBL1649741;C34H48O7.2Na;3-beta-Hydroxy-11-oxoolean-12-en-30-oic acid hydrogen succinate, disodium salt;3-O-(beta-Carboxypropionyl)-11-oxo-18-beta-olean-12-en-30-oic acid, disodium salt;Olean-12-en-30-oic acid, 3-beta-hydroxy-11-oxo-, hydrogen succinate, disodium salt;Olean-12-en-29-oic acid, 3-(3-carboxy-1-oxopropoxy)-11-oxo, disodium salt, (3beta,20beta)-;Olean-12-en-29-oic acid, 3-(3-carboxy-1-oxopropoxy)-11-oxo-, disodium salt, (3-beta,20-beta)-;LS-98302

Chemical Property of Pyrogastrone

Chemical Property:

• Vapor Pressure: 1.06E-20mmHg at 25°C
• Melting Point: >275°C (dec.)
• Boiling Point: 687.4oC at 760 mmHg
• PKA: pKa1 4.18; pKa2 5.52(at 25℃)
• Flash Point: 211.6oC
• PSA: 123.63000
• LogP: 4.15890
• Storage Temp.: 2-8°C
• Solubility.: Methanol (Slightly), Water (Slightly)
• Water Solubility.: Soluble in water to 100 mM.
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 614.31954243
• Heavy Atom Count: 43
• Complexity: 1190

Purity/Quality:

98%,99%, ^*data from raw suppliers

Carbenoxolone disodium ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 22-36
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1(C2CCC3(C(C2(CCC1OC(=O)CCC(=O)[O-])C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)[O-])C)C)C)C.[Na+].[Na+]
• Isomeric SMILES: C[C@@]1(CCC2(CC[C@@]3(C(=CC(=O)[C@H]4C3(CC[C@@H]5C4(CC[C@@H](C5(C)C)OC(=O)CCC(=O)[O-])C)C)C2C1)C)C)C(=O)[O-].[Na+].[Na+]
• Recent EU Clinical Trials: Cortisol metabolism and impaired glucose tolerance
• Uses: Carbenoxolone is anti-inflammatory. It is often used as a gap junction inhibitor in neuroscience research. Carbenoxolone is also an inhibitor of the steroid dehydrogenase enzymes 11 β-hydroxysteroid dehydrogenase (human) and 3α, 20 β-hydroxysteroid dehydrogenase (bacterial). It is used for the treatment of digestive tract ulcers, especially in the stomach. Used in the treatment of peptic, mainly gastric, ulcers. It is often used as a gap junction inhibitor in neuroscience research. Anti-inflammatory glucocorticoid related to Enoxolone. Antiulcerative beta-adrenergic agonist, growth stimulant