Chloroprocaine hydrochloride

Base Information

• Chemical Name: Chloroprocaine hydrochloride
• CAS No.: 3858-89-7
• Molecular Formula: C13H19 Cl N2 O2 . Cl H
• Molecular Weight: 307.22
• Hs Code.: DERIVATION
• European Community (EC) Number: 223-371-2
• UNII: LT7Z1YW11H
• DSSTox Substance ID: DTXSID6048595
• Wikidata: Q27068150
• NCI Thesaurus Code: C47444
• RXCUI: 53616
• ChEMBL ID: CHEMBL944
• Mol file: 3858-89-7.mol

Synonyms:2-chloroprocaine;chlor-procaine;chloroprocaine;chloroprocaine hydrochloride;Nesacaine;Nesacaine MPF

Chemical Property of Chloroprocaine hydrochloride

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 1.08E-06mmHg at 25°C
• Melting Point: 176-178° (microstage)
• Boiling Point: 402.6 °C at 760 mmHg
• Flash Point: 197.3 °C
• PSA: 41.57000
• LogP: 3.62590
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 306.0901833
• Heavy Atom Count: 19
• Complexity: 259

Purity/Quality:

99% ^*data from raw suppliers

Chloroprocaine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): UN NO.
• Hazard Codes: UN NO.

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl.Cl
• Recent EU Clinical Trials: A Phase II/III, Randomized, Double-Masked, Vehicle-Controlled, Efficacy, Safety and Tolerability Study of Chloroprocaine 3% Gel Eye Drops in healthy volunteers
• Uses: Chloroprocaine Hydrochloride is a local anaesthetic compound showing similar effects to Lidocaine. Anesthetic (local).
• Therapeutic Function: Local anesthetic

Technology Process of Chloroprocaine hydrochloride

There total 2 articles about Chloroprocaine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(diethylamino)ethyl 2-chloro-4-nitrobenzoate (10367-96-1) → chloroprocaine hydrochloride (3858-89-7)

Guidance literature:

With iron; ammonium chloride; In water; at 68 - 70 ℃; Temperature;

Reference yield:

4-amino-2-chlorobenzoic acid (2457-76-3) + N,N-diethylethanolammonium chloride (14426-20-1) → chloroprocaine hydrochloride (3858-89-7)

Guidance literature:

With thionyl chloride;

DOI:10.1021/ja01208a027

upstream raw materials:

4-amino-2-chlorobenzoic acid

N,N-diethylethanolammonium chloride

2-(diethylamino)ethyl 2-chloro-4-nitrobenzoate

Refernces