Technology Process of (E)-3-(7-oxo-1,5,6,7-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid
There total 4 articles about (E)-3-(7-oxo-1,5,6,7-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
for 0.5h;
DOI:10.1021/jm0204035
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 45 percent / Pd(OAc)2; P(tolyl)3; DIEA / various solvent(s); dimethylformamide / 18 h / Heating
2: 100 percent / TFA / CH2Cl2 / 0.5 h
With
palladium diacetate; P(tolyl)3; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
dichloromethane; N,N-dimethyl-formamide;
1: Heck coupling;
DOI:10.1021/jm0204035
- Guidance literature:
-
Multi-step reaction with 4 steps
1: aq. NaOH / methanol / 4 h / Heating
2: aq. HCl / Heating
3: 45 percent / Pd(OAc)2; P(tolyl)3; DIEA / various solvent(s); dimethylformamide / 18 h / Heating
4: 100 percent / TFA / CH2Cl2 / 0.5 h
With
hydrogenchloride; palladium diacetate; sodium hydroxide; P(tolyl)3; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
3: Heck coupling;
DOI:10.1021/jm0204035