335031-10-2

Basic information

• Product Name: METHYL 6-BROMO-2-OXO-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXYLATE
• Synonyms: METHYL 6-BROMO-2-OXO-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXYLATE;Methyl 6-bromo-2-oxo-2,3,4,8-tetrahydro-1,8-naphthyridine-3-carboxylate;6-Bromo-1,2,3,4-tetrahydro-2-oxo-1,8-naphthyridine-3-carboxylic Acid Methyl Ester;Methyl 6-broMo-2-oxo-1,2,...;6-BroMo-2-oxo-1,2,3,4-tetrahydro-[1,8]naphthyridine-3-carboxylic acid Methyl ester;1,8-Naphthyridine-3-carboxylic acid, 6-bromo-1,2,3,4-tetrahydro-2-oxo-, methyl ester
• CAS NO: 335031-10-2
• Molecular Formula: C₁₀H₉BrN₂O₃
• Molecular Weight: 285.09
• Product Categories: Aromatics;Heterocycles;Intermediates
• Mol File: 335031-10-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 438.965 °C at 760 mmHg
• Flash Point: 219.279 °C
• Appearance: /
• Density: 1.622 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.582
• Solubility: DMSO, Methanol
• PKA: 11.43±0.40(Predicted)
• CAS DataBase Reference: METHYL 6-BROMO-2-OXO-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 6-BROMO-2-OXO-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXYLATE(335031-10-2)
• EPA Substance Registry System: METHYL 6-BROMO-2-OXO-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXYLATE(335031-10-2)

Safety Data

• Hazardous Substances Data: 335031-10-2(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

Intermediate in the production of FabI inhibitors

InChI:InChI=1/C10H9BrN2O3/c1-16-10(15)7-3-5-2-6(11)4-12-8(5)13-9(7)14/h2,4,7H,3H2,1H3,(H,12,13,14)

Upstream product

• 443956-55-6 (2-amino-5-bromopyridine-3-yl)methanol hydrobromide 
• 335031-01-1 2-amino-5-bromo-3-(hydroxymethyl)pyridine 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 23612-57-9 (2-amino-3-pyridinyl)methanol 
• 108-59-8 malonic acid dimethyl ester 
• 335033-38-0 2-amino-5-bromo-3-(bromomethyl)pyridine hydrobromide 

Downstream Products

• 1309205-56-8 6-{(1E)-3-[4-hydroxy-4-phenylpiperidin-1-yl]-3-oxoprop-1-en-1-yl}-3,4-dihydro-1,8-naphthyridin-2(1H)-one 
• 1309205-75-1 methyl 6-[(1E)-3-{4-[(4-fluorophenoxy)methyl]piperidin-1-yl}-3-oxoprop-1-en-1-yl]-2-oxo-1,2,3,4-tetrahydro-1,8-naphthyridine-3-carboxylate 
• 1309351-04-9 3-(hydroxymethyl)-6-[(1E)-3-{4-[(4-fluorophenoxy)methyl]piperidin-1-yl}-3-oxoprop-1-en-1-yl]-3,4-dihydro-1,8-naphthyridin-2(1H)-one 
• 1309205-40-0 6-[(1E)-3-{[4-(4-fluorophenoxy)methyl]piperidin-1-yl}-3-oxoprop-1-en-1-yl]-3,4-dihydro-1,8-naphthyridin-2(1H)-one 
• 1023813-80-0 6-bromo-1,2,3,4-tetrahydro-[1,8]naphthyridine 
• 1309205-48-8 6-[(1E)-3-oxo-3-(3-phenoxypyrrolidin-1-yl)prop-1-en-1-yl]-3,4-dihydro-1,8-naphthyridin-2(1H)-one 
• 1309205-47-7 6-[(1E)-3-{[3-(4-fluorophenoxy)methyl]piperidin-1-yl}-3-oxoprop-1-en-1-yl]-3,4-dihydro-1,8-naphthyridin-2(1H)-one 
• 1309205-45-5 6-[(1E)-3-oxo-3-(2-phenylpyrrolidin-1-yl)prop-1-en-1-yl]-3,4-dihydro-1,8-naphthyridin-2(1H)-one 
• 1309205-42-2 (E)-6-(3-oxo-3-(3-phenoxyazetidin-1-yl)prop-1-en-1-yl)-3,4-dihydro-1,8-naphthyridin-2(1H)-one 
• 527758-08-3 (E)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid 
• 129686-16-4 6-bromo-3,4-dihydro-1,8-naphthyridine-2(1H)-one 

Relevant articles and documents

Alkenyl compound and its method and use thereof

The invention provides a new substituted alkenyl compound, pharmaceutically acceptable salts of the new substituted alkenyl compound, a medicinal preparation of the new substituted alkenyl compound, and application of the new substituted alkenyl compound, the pharmaceutically acceptable salts and the medicinal preparation of the new substituted alkenyl compound in aspects of regulating the activity of protein kinase and regulating the intercellular or intracellular signal response. The invention also relates to a medicament composition containing the compound at the same time, and relates to a method for treating high-proliferative diseases of mammals especially the human by using the medicament composition.

SUBSTITUTED PYRIDINE DERIVATIVES AS FABI INHIBITORS

The present invention provides substituted pyridine derivatives of formula (I), which may be therapeutically useful as as anti-bacterial agents, more particulalrly FabI inhibitors. Formula(I) in which R1 to R5 and L have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage anti-bacterial agents, more particularly FabI inhibitors. The present invention also provides methods for synthesizing and administering the FabI inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the FabI inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

FAB I INHIBITORS

Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.