ETHANOL, 2-(o-BIPHENYLYLOXY)-

Base Information

• Chemical Name: ETHANOL, 2-(o-BIPHENYLYLOXY)-
• CAS No.: 7501-02-2
• Molecular Formula: C14H14O2
• Molecular Weight: 214.264
• NSC Number: 408053
• UNII: 29PW8VF2JZ
• DSSTox Substance ID: DTXSID80225991
• Nikkaji Number: J49.820C
• Wikidata: Q72443726
• Mol file: 7501-02-2.mol

Synonyms:7501-02-2;ETHANOL, 2-(o-BIPHENYLYLOXY)-;2-(2-phenylphenoxy)ethanol;2-([1,1'-Biphenyl]-2-yloxy)ethanol;Ethanol, 2-(2-biphenylyloxy)-;2-(2-BIPHENYLYLOXY)ETHANOL;Ethanol, 2-([1,1'-biphenyl]-2-yloxy)-;Ethyl alcohol, 2-(o-biphenylyloxy)-;Ethyl alcohol, 2-(o-phenyl)phenoxy-;2-(2-Biphenyl)oxyethanol;29PW8VF2JZ;beta-Hydroxyethyl ether of o-phenylphenol;.beta.-Hydroxyethyl ether of o-phenylphenol;Ethanol, 2-((1,1'-biphenyl)-2-yloxy)-;NSC 408053;NSC-408053;BRN 3270034;AI3-22279;2-[(1,1'-Biphenyl)-2-yloxy]ethanol;2-((1,1'-BIPHENYL)-2-YLOXY)ETHANOL;NEWPOL OPE 10;UNII-29PW8VF2JZ;WLN: Q2OR BR;2-(2-Biphenyloxy)-ethanol;2-(biphenyl-2-yloxy)ethanol;SCHEMBL159005;DTXSID80225991;methyl?3-hydroxy-4-nitrobenzoate;Ethanol,1'-biphenyl]-2-yloxy)-;NSC408053;LS-66485;O-PHENYLPHENOL 2-HYDROXYETHYL ETHER;2-([1,1'-Biphenyl]-2-yloxy)ethanol #;CS-0438493;N16843;4-06-00-04581 (Beilstein Handbook Reference)

Chemical Property of ETHANOL, 2-(o-BIPHENYLYLOXY)-

Chemical Property:

• Vapor Pressure: 2.47E-05mmHg at 25°C
• Refractive Index: 1.575
• Boiling Point: 344.6 °C at 760 mmHg
• PKA: 14.24±0.10(Predicted)
• Flash Point: 151.4 °C
• PSA: 29.46000
• Density: 1.111 g/cm³
• LogP: 2.72470
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 214.099379685
• Heavy Atom Count: 16
• Complexity: 187

Purity/Quality:

99%, ^*data from raw suppliers

2-(2-BIPHENYLYLOXY)ETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=CC=C2OCCO

Technology Process of ETHANOL, 2-(o-BIPHENYLYLOXY)-

There total 5 articles about ETHANOL, 2-(o-BIPHENYLYLOXY)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%

[1,3]-dioxolan-2-one (96-49-1) + 2-Phenylphenol (90-43-7,287950-96-3) → 2-(<1,1'-biphenyl>2-yloxy)ethanol (7501-02-2,32171-23-6)

Guidance literature:

With potassium carbonate; at 160 ℃; for 1h; Temperature; Reagent/catalyst;

Reference yield: 95.0%

ethyl (<1,1'-biphenyl>-2-yloxy)acetate (107352-46-5) → 2-(<1,1'-biphenyl>2-yloxy)ethanol (7501-02-2,32171-23-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1021/jm00388a035

Reference yield:

2-Phenylphenol (90-43-7,287950-96-3) → 2-(<1,1'-biphenyl>2-yloxy)ethanol (7501-02-2,32171-23-6)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 4 h

2: LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja0547230

upstream raw materials:

2-Phenylphenol

2-chloro-ethanol

ethyl (<1,1'-biphenyl>-2-yloxy)acetate

[1,3]-dioxolan-2-one

Downstream raw materials:

3-(2-biphenyl-2-yloxy-ethoxy)-phthalide

2-phenylphenoxyethyl acrylate

1-<2-(<1,1'-biphenyl>-2-yloxy)ethyl>-1H-imidazole

Refernces

• 1、 Wood, Warren J. L.,Patterson, Andrew W.,Tsuruoka, Hiroyuki,Jain, Rishi K.,Ellman, Jonathan A.. "Substrate activity screening: A fragment-based method for the rapid identification of nonpeptidic protease inhibitors". . p. 15521 - 15527. Retrieved 2007/10/03.