Prolixin

Base Information

• Chemical Name: Prolixin
• CAS No.: 146-56-5
• Molecular Formula: C22H28Cl2F3N3OS
• Molecular Weight: 510.451
• Hs Code.: 2934302300
• NSC Number: 757816,179197,62323
• NCI Thesaurus Code: C47995
• RXCUI: 203207
• ChEMBL ID: CHEMBL1200792
• Mol file: 146-56-5.mol

Synonyms:Flufenazin;Fluphenazine;Fluphenazine Hydrochloride;Hydrochloride, Fluphenazine;Lyogen;Prolixin

Chemical Property of Prolixin

Chemical Property:

• Appearance/Colour: Off-white solid
• Vapor Pressure: 9.41E-14mmHg at 25°C
• Melting Point: 200-202 °C
• Boiling Point: 568.3 °C at 760 mmHg
• Flash Point: 297.5 °C
• PSA: 55.25000
• LogP: 5.85290
• Storage Temp.: -20°C Freezer
• Sensitive.: Hygroscopic
• Solubility.: Soluble in DMSO and methanol.
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 6
• Exact Mass: 473.1515458
• Heavy Atom Count: 31
• Complexity: 544

Purity/Quality:

99% ^*data from raw suppliers

Fluphenazine Dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36/37/39-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO.Cl
• Recent ClinicalTrials: Fluphenazine in Treating Patients With Refractory Advanced Multiple Myeloma
• Uses: antiandrogen, antineoplastic, Nuclear Hormone receptor antagonist Antipsychotic
• Therapeutic Function: Tranquilizer

Technology Process of Prolixin

There total 1 articles about Prolixin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ fluphenazine dihydrochloride (146-56-5)

Guidance literature:

2-Trifluormethyl-phenothiazin, 1-(3-Chlorpropyl)-4-(2-hydroxyaethyl)-piperazin;

Reference yield: 70.0%

fluphenazine dihydrochloride (146-56-5) → Fluphenazinsulfoxid (1674-76-6)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; for 0.0333333h; chemoselective reaction;

DOI:10.1016/j.xphs.2018.10.059

Reference yield:

fluphenazine dihydrochloride (146-56-5) + 2,4,6-Trinitrophenol (88-89-1) → 2C6H3N3O7*C22H26F3N3OS

Guidance literature:

In methanol; at 59.84 ℃; for 1h;

DOI:10.1007/s10870-010-9773-z

Downstream raw materials:

Fluphenazinsulfoxid