CAS No.146-56-5,FLUPHENAZINE HYDROCHLORIDE Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	146-56-5
Name:	FLUPHENAZINE HYDROCHLORIDE

Formula:	C₂₂H₂₈Cl₂F₃N₃OS
Molecular Weight:	510.451
Synonyms:	查看更多英文别名收起"> fluorophenazine dihydrochloride;Fluphenazine dihydrochloride;Lyorodin;Mirenil;Prolixin;Anatensol;Fluphenazindihydrochlorid;4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol dihydrochloride;Fluphenazine hydrochloride;fluphenazine dihydrodchloride;Tensofin;Moditen;Trancin;查看更多英文别名收起
EINECS:	205-674-1
Melting Point:	200-202 °C
Boiling Point:	568.3 °C at 760 mmHg
Flash Point:	297.5 °C
Appearance:	Off-white solid
Hazard Symbols:	Xn
Risk Codes:	36/37/38-20/21/22
Safety:	26-36/37/39-36
Transport Information:	UN 2811
PSA:	55.25000
LogP:	5.85290

Synthetic route

: 146-56-5
fluphenazine dihydrochloride

: 1674-76-6
fluphenazine-sulfoxide

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In water for 0.0333333h; chemoselective reaction;	70%

: 146-56-5
fluphenazine dihydrochloride

chloramine-T: chloramine-T

: 2-{4-[3-(5-oxo-2-trifluoromethyl-5H-5λ4-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethanol; compound with GENERIC INORGANIC NEUTRAL COMPONENT

Conditions

Conditions	Yield
In water at 30℃; pH=1.6; Kinetics; Further Variations:; pH-values; Temperatures; variation of ionic strength, dielectric constant of the medium + halides;

: 146-56-5
fluphenazine dihydrochloride

: copper dichloride

: 81504-38-3
{C12H7NS(CF3)(CH2CH2CH2(C4H8N2)CH2CH2OH)}CuCl2(H2O)2

Conditions

Conditions	Yield
In acetone soln. of CuCl2 in acetone mixed with soln. of organic compound in acetone, benzene added, mixture concentrated on a heating mantle at 60-70°C; filtered, washed with benzene followed by ether, dried in vac.; elem. anal.;

: 146-56-5
fluphenazine dihydrochloride

: 88-89-1
2,4,6-Trinitrophenol

: 2C6H3N3O7*C22H26F3N3OS

Conditions

Conditions	Yield
In methanol at 59.84℃; for 1h;

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Chemistry

Chemistry informtion about Fluphenazine Dihydrochloride (CAS NO.146-56-5) is:
IUPAC Name: 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol dihydrochloride
Synonyms: 10-(3-(4-(2-Hydroxyethyl)Piperazinyl)Propyl)-2-Trifluoromethylphenothiazine ; 4-(3-(2-(Trifluoromethyl)Phenothiazin-10-Yl)Propyl)-1-Piperazineethanodihy ; 4-(3-(2-(Trifluoromethyl)Phenothiazin-10-Yl)Propyl)-1-Piperazineethanol,Dihy ; 4-[3[2-(Trifluoromethyl)-10h-Phenothiazin-10-Yl]Propyl]-1-Piperazineethano ; A4077 ; Anatensol ; Flufenazin ; Liogen
Product Categories: Active Pharmaceutical Ingredients ; Organics ; Heterocyclic Compounds ; Heterocycles ; Intermediates & Fine Chemicals ; Pharmaceuticals ; Sulfur & Selenium Compounds
MF: C₂₂H₂₈Cl₂F₃N₃OS
MW: 510.44
EINECS: 205-674-1
Melting Point: 200-2020°C
Flash Point: 297.5 °C
Boiling Point: 568.3 °C at 760 mmHg
Vapour Pressure: 9.41E-14 mmHg at 25°C
Enthalpy of Vaporization: 89.73 kJ/mol
Sensitive: Hygroscopic
Following is the molecular structure of Fluphenazine Dihydrochloride (CAS NO.146-56-5) is:

Uses

Fluphenazine Dihydrochloride (CAS NO.146-56-5) can be used as Antipsychotic.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	intraperitoneal	299mg/kg (299mg/kg)		Pharmazie. Vol. 38, Pg. 749, 1983.
human	TDLo	oral	2800ug/kg/2W- (2.8mg/kg)	musculoskeletal: other changes	British Medical Journal. Vol. 2, Pg. 1071, 1966.
mouse	LD50	intraperitoneal	89mg/kg (89mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 24, 1972.
mouse	LD50	intravenous	56mg/kg (56mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00179,
mouse	LD50	oral	220mg/kg (220mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 24, 1972.

Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. Human systemic effects by ingestion: musculo-skeletal changes. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl, SO_x, NO_x, and F⁻.
Hazard Codes:
Harmful Xn
Risk Statements:
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S36:Wear suitable protective clothing.
RIDADR: UN2811
RTECS: TL9800000
HazardClass: 6.1
PackingGroup: III

Specification

Fluphenazine Dihydrochloride (CAS NO.146-56-5) is a off-white solid.