N-Methyl-N-formylhydrazine

Base Information

• Chemical Name: N-Methyl-N-formylhydrazine
• CAS No.: 758-17-8
• Molecular Formula: C2H6N2O
• Molecular Weight: 74.0824
• NSC Number: 122452
• UNII: 3L13R06H7D
• DSSTox Substance ID: DTXSID2020840
• Nikkaji Number: J34.716G
• Wikidata: Q27257474
• Mol file: 758-17-8.mol

Synonyms:N-methyl-N-formylhydrazine

Chemical Property of N-Methyl-N-formylhydrazine

Chemical Property:

• Vapor Pressure: 16.6mmHg at 25°C
• Melting Point: 219-222 °C(Solv: ethanol (64-17-5))
• Refractive Index: 1.4368 (estimate)
• Boiling Point: 118.6°C at 760 mmHg
• PKA: 3.12±0.10(Predicted)
• Flash Point: 25.5°C
• PSA: 46.33000
• Density: 1.061g/cm³
• LogP: 0.28450
• XLogP3: -1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 74.048012819
• Heavy Atom Count: 5
• Complexity: 36.6

Purity/Quality:

99%, ^*data from raw suppliers

N-Methyl-N-formylhydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Hydrazides
• Canonical SMILES: CN(C=O)N

Technology Process of N-Methyl-N-formylhydrazine

There total 7 articles about N-Methyl-N-formylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

formic acid (64-18-6) + methylhydrazine (60-34-4) → 1-Methyl-1-formylhydrazid (758-17-8)

Guidance literature:

In di-isopropyl ether; for 90h; Heating;

Reference yield: 75.0%

methylhydrazine (60-34-4) + formic acid ethyl ester (109-94-4) → 1-Methyl-1-formylhydrazid (758-17-8) + 1-formyl-2-methylhydrazine (155106-68-6)

Guidance literature:

In ethanol; for 6h; Reflux;

DOI:10.1002/asia.201100769

Reference yield:

Methyl formate (107-31-3) + methylhydrazine (60-34-4) → 1-Methyl-1-formylhydrazid (758-17-8)

Guidance literature:

DOI:10.1002/ardp.19713040912

upstream raw materials:

formic acid

methylhydrazine

Methyl formate

ethyl formimidate hydrochloride

Downstream raw materials:

Formic acid N'-dec-(Z)-ylidene-N-methyl-hydrazide

Pentanal-N-methyl-N-formyl-hydrazon

N¹-Methyl-N¹-formyl-N₂-(4-nitro-benzyliden)-hydrazin

Gyromitrin

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS FOR INHIBITING TYK2 ACTIVITIES". Page/Page column 16-17. . Retrieved 2021/09/17.
• 2、 -. "PROCESS FOR THE PREPARATION OF 6-(CYCLOPROPANEAMIDO)-4-((2-METHOXY-3-(1-METHYL-1H-1,2,4-TRIAZOL-3-YL)PHENYL)AMINO)-N-(METHYL-D3)PYRIDAZINE-3-CARBOXAMIDE". Page/Page column 21-22. . Retrieved 2018/10/25.