Technology Process of 5-benzyloxy-2-(tert-butyldiphenylsilyl)oxy-3-hydroxy-D-ribonolactone
There total 7 articles about 5-benzyloxy-2-(tert-butyldiphenylsilyl)oxy-3-hydroxy-D-ribonolactone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; trifluoroacetic acid; zinc;
In
toluene;
at 20 ℃;
for 72h;
DOI:10.1021/ja502205q
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 20 °C
2: copper dichloride; (R)-5-((1-Benzyl-1H-indol-3-yl)methyl)-2,2,3-trimethylimidazolin-4-one tetrafluoroboric acid / ethyl acetate / 24 h / -30 °C / Molecular sieve
3: titanium(IV) dichlorodiisopropylate / dichloromethane / 16 h / -20 °C / Inert atmosphere
4: zinc; water; trifluoroacetic acid / toluene / 72 h / 20 °C
With
titanium(IV) dichlorodiisopropylate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; (R)-5-((1-Benzyl-1H-indol-3-yl)methyl)-2,2,3-trimethylimidazolin-4-one tetrafluoroboric acid; water; trifluoroacetic acid; copper dichloride; zinc;
In
dichloromethane; ethyl acetate; toluene;
3: |Mukaiyama Aldol Addition;
DOI:10.1021/ja502205q
- Guidance literature:
-
Multi-step reaction with 3 steps
1: copper dichloride; CHF3O3S*C13H18N2O / diethyl ether / 48 h / -30 °C / Molecular sieve; Inert atmosphere
2: titanium(IV) dichlorodiisopropylate / dichloromethane / 16 h / -20 °C / Inert atmosphere
3: zinc; water; trifluoroacetic acid / toluene / 72 h / 20 °C
With
titanium(IV) dichlorodiisopropylate; CHF3O3S*C13H18N2O; water; trifluoroacetic acid; copper dichloride; zinc;
In
diethyl ether; dichloromethane; toluene;
2: |Mukaiyama Aldol Addition;
DOI:10.1021/ja502205q