Technology Process of (2R,3R,4R)-isopropyl 5-(benzyloxy)-3-hydroxy-2-((tert-butyldiphenylsilyl)oxy)-4-(2,2,6,6-tetramethylpiperidin-1-yloxy)pentanoate
There total 6 articles about (2R,3R,4R)-isopropyl 5-(benzyloxy)-3-hydroxy-2-((tert-butyldiphenylsilyl)oxy)-4-(2,2,6,6-tetramethylpiperidin-1-yloxy)pentanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
titanium(IV) dichlorodiisopropylate;
In
dichloromethane;
at -20 ℃;
for 16h;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1021/ja502205q
- Guidance literature:
-
Multi-step reaction with 2 steps
1: copper dichloride; CHF3O3S*C13H18N2O / diethyl ether / 48 h / -30 °C / Molecular sieve; Inert atmosphere
2: titanium(IV) dichlorodiisopropylate / dichloromethane / 16 h / -20 °C / Inert atmosphere
With
titanium(IV) dichlorodiisopropylate; CHF3O3S*C13H18N2O; copper dichloride;
In
diethyl ether; dichloromethane;
2: |Mukaiyama Aldol Addition;
DOI:10.1021/ja502205q
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 0 °C
1.2: 16 h / 20 °C
2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 20 °C
3.1: copper dichloride; (R)-5-((1-Benzyl-1H-indol-3-yl)methyl)-2,2,3-trimethylimidazolin-4-one tetrafluoroboric acid / ethyl acetate / 24 h / -30 °C / Molecular sieve
4.1: titanium(IV) dichlorodiisopropylate / dichloromethane / 16 h / -20 °C / Inert atmosphere
With
titanium(IV) dichlorodiisopropylate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; (R)-5-((1-Benzyl-1H-indol-3-yl)methyl)-2,2,3-trimethylimidazolin-4-one tetrafluoroboric acid; sodium hydride; copper dichloride;
In
dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
4.1: |Mukaiyama Aldol Addition;
DOI:10.1021/ja502205q
