Tropine-3-mesylate

Base Information

• Chemical Name: Tropine-3-mesylate
• CAS No.: 35130-97-3
• Molecular Formula: C9H17 N O3 S
• Molecular Weight: 219.305
• Hs Code.: 2933990090
• Mol file: 35130-97-3.mol

Synonyms:8-Azabicyclo[3.2.1]octan-3-ol,8-methyl-, methanesulfonate (ester), (3-endo)- (9CI);8-Azabicyclo[3.2.1]octan-3-ol, 8-methyl-, methanesulfonate (ester), endo-;Tropine methanesulfonate (6CI);O-Methanesulfonyltropine;Tropan-3a-yl methanesulfonate;Tropine3-mesylate;endo-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl methanesulfonate;

Chemical Property of Tropine-3-mesylate

Chemical Property:

• Vapor Pressure: 5.5E-05mmHg at 25°C
• Refractive Index: 1.53
• Boiling Point: 347.1°Cat760mmHg
• Flash Point: 163.7°C
• PSA: 54.99000
• Density: 1.25g/cm³
• LogP: 1.60650

Purity/Quality:

99.9% ^*data from raw suppliers

endo-8-Methyl-8-azabicyclo[3.2.1]octan-3-ylmethanesulfonate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tropine-3-mesylate

There total 1 articles about Tropine-3-mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methanesulfonyl chloride (124-63-0) + 3-tropanol (120-29-6) → (1R,3R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl-methane sulfonate (35130-97-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tetlet.2006.10.015

Reference yield: 85.6%

(1R,3R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl-methane sulfonate (35130-97-3) + potassium ethyl xanthogenate (140-89-6) → C11H19NOS2*H2O4S

Guidance literature:

(1R,3R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl-methane sulfonate; potassium ethyl xanthogenate; In water; at 25 ℃; for 2h;

With sulfuric acid; In ethanol; pH=6 - 7;

Reference yield: 85.1%

(1R,3R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl-methane sulfonate (35130-97-3) + sodium N,N-diethyldithiocarbamate (148-18-5) → (1R,3S,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3-yldiethylaminodithiocarbamate

Guidance literature:

In N,N-dimethyl-formamide; at 120 ℃; for 1h; Solvent; Temperature; Green chemistry;

upstream raw materials:

methanesulfonyl chloride

3-tropanol

Downstream raw materials:

3α-cyanotropane

3-endo-benzylamino-8-methyl-8-azabicyclo[3.2.1]octane

thioacetic acid S-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl) ester

tropane-3-carboxamide

Refernces

• 1、 -. "Process for the preparation of Retapamulin and its intermediates". Page/Page column 3; 5. . Retrieved 2009/06/27.