Tobramycin sulfate

Base Information

• Chemical Name: Tobramycin sulfate
• CAS No.: 49842-07-1
• Molecular Formula: C₁₈H₃₇N₅O₉*H₂O₄S
• Molecular Weight: 565.599
• Hs Code.: 2941900000
• European Community (EC) Number: 256-499-2,616-717-2
• NCI Thesaurus Code: C893
• RXCUI: 7276
• ChEMBL ID: CHEMBL1200780
• Mol file: 49842-07-1.mol

Synonyms:Brulamycin;Nebcin;Nebicin;Nebramycin Factor 6;Obracin;Sulfate, Tobramycin;Tobracin;Tobramycin;Tobramycin Sulfate

Chemical Property of Tobramycin sulfate

Chemical Property:

• Vapor Pressure: 9.05E-28mmHg at 25°C
• Boiling Point: 775.4 °C at 760 mmHg
• Flash Point: 422.8 °C
• PSA: 351.15000
• Density: 1.52g/cm3
• LogP: -2.36630
• Storage Temp.: 2-8°C
• Water Solubility.: Soluble in water (50 mg/ml).
• Hydrogen Bond Donor Count: 12
• Hydrogen Bond Acceptor Count: 18
• Rotatable Bond Count: 6
• Exact Mass: 565.22650749
• Heavy Atom Count: 37
• Complexity: 691

Purity/Quality:

99% ^*data from raw suppliers

Tobramycin sulfate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 61-20/21/22
• Safety Statements: 53-22-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(CC(C(O3)CN)O)N)N.OS(=O)(=O)O
• Isomeric SMILES: C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H](C[C@@H]([C@H](O3)CN)O)N)N.OS(=O)(=O)O
• Recent ClinicalTrials: Evaluation of Short Antibiotic Combination Courses Followed by Aerosols in Cystic Fibrosis
• Recent EU Clinical Trials: Short course antibiotic treatment of Gram-negative bacteremia: A multicenter, randomized, non-blinded, non-inferiority interventional study
• Uses: Nebcin (Lilly). Tobramycin sulfate is used as an antibiotic which is used to treat various types of bacterial infections, particularly Gram-negative infections. It is especially effective against species of Pseudomonas. It is used to inhibit bacterial protein synthesis at the level of 30S (16S rRNA) and 70S ribosomal complex assembly. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis and other soft-tissue infections. It is a potential therapy for sinus infections1. Product T1783 has been used to study antibiotic resistance2.
• Therapeutic Function: Antibiotic
• Clinical Use: Introduced in 1976, tobramycin sulfate (Nebcin) is the mostactive of the chemically related aminoglycosides called nebramycinsobtained from a strain of Streptomyces tenebrarius Five members of the nebramycin complex have beenidentified chemically.Factors 4 and 4＇ are 6＂-O-carbamoylkanamycin B andkanamycin B, respectively; factors 5＇ and 6 are 6＂-O-carbamoyltobramycinand tobramycin; and factor 2 isapramycin, a tetracyclic aminoglycoside with an unusual bicycliccentral ring structure. Kanamycin B and tobramycinprobably do not occur in fermentation broths per se but areformed by hydrolysis of the 6-O＂-carbamoyl derivatives inthe isolation procedure.The most important property of tobramycin is its activityagainst most strains of P. aeruginosa, exceeding that of gentamicinby twofold to fourfold. Some gentamicin-resistantstrains of this troublesome organism are sensitive to tobramycin,but others are resistant to both antibiotics. OtherGram-negative bacilli and staphylococci are generally moresensitive to gentamicin. Tobramycin more closely resembleskanamycin B in structure (it is 3＇-deoxykanamycin B).