tert-butyl 4-(2-perfluoroctylethyl)benzyloxycarbamate

Base Information

• Chemical Name: tert-butyl 4-(2-perfluoroctylethyl)benzyloxycarbamate
• CAS No.: 1313585-45-3
• Molecular Formula: C₂₂H₂₀F₁₇NO₃
• Molecular Weight: 669.379
• Mol file: 1313585-45-3.mol

Synonyms:tert-butyl 4-(2-perfluoroctylethyl)benzyloxycarbamate

Chemical Property of tert-butyl 4-(2-perfluoroctylethyl)benzyloxycarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(2-perfluoroctylethyl)benzyloxycarbamate

There total 2 articles about tert-butyl 4-(2-perfluoroctylethyl)benzyloxycarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-Butyl N-hydroxycarbamate (36016-38-3) + 1-(bromomethyl)-4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)benzene → tert-butyl 4-(2-perfluoroctylethyl)benzyloxycarbamate (1313585-45-3)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at -5 - 20 ℃; Inert atmosphere; Darkness;

DOI:10.1016/j.tet.2011.05.039

Reference yield:

(4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)phenyl)methanol (356055-77-1) → tert-butyl 4-(2-perfluoroctylethyl)benzyloxycarbamate (1313585-45-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfurous dibromide / tetrahydrofuran / 0 - 20 °C / Inert atmosphere; Darkness

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / -5 - 20 °C / Inert atmosphere; Darkness

With sulfurous dibromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran;

DOI:10.1016/j.tet.2011.05.039

Reference yield: 100.0%

tert-butyl 4-(2-perfluoroctylethyl)benzyloxycarbamate (1313585-45-3) + 4-Methylbenzyl bromide (104-81-4) → tert-butyl (4-methylbenzyl)(4-(2-perfluoroctylethyl)benzyloxy)carbamate (1313585-50-0)

Guidance literature:

With caesium carbonate; In acetonitrile; at 45 ℃; for 3h;

DOI:10.1016/j.tet.2011.05.039

upstream raw materials:

tert-Butyl N-hydroxycarbamate

(4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)phenyl)methanol

Downstream raw materials:

tert-butyl (5-(indolin-1-yl)-5-oxopentyl)(4-(2-perfluoroctyl-ethyl)benzyloxy)carbamate

tert-butyl (3-(3-acetyl-1H-indol-1-yl)propyl)((4-(2-perfluoroctylethyl)benzyl)oxy)carbamate

N-methyl-O-(4-(2-perfluoroctylethyl)benzyl)hydroxylamine hydrochloride

ethyl 7-(((4-(2-perfluoroctylethyl)benzyl)oxy)amino)heptanoate hydrochloride

Refernces