Ecabet sodium

Base Information

• Chemical Name: Ecabet sodium
• CAS No.: 86408-72-2
• Molecular Formula: C20H28O5S . Na
• Molecular Weight: 402.487
• Mol file: 86408-72-2.mol

Synonyms:1-Phenanthrenecarboxylicacid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-,monosodium salt, (1R,4aS,10aR)- (9CI);Gastrom;TA 2711;

Chemical Property of Ecabet sodium

Chemical Property:

• Melting Point: >300°
• Refractive Index: 1.562
• PSA: 102.88000
• Density: 1.241 g/cm^3/sup>
• LogP: 4.88980

Purity/Quality:

99% ^*data from raw suppliers

Ecabet(sodiumsalt) >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Ecabet sodium is a new antiulcer agent launched in Japan for the treatment of gastric ulcer. It has both mucosal-protective and tissue-repairing properties. In rats, it effectively prevents gastrointestinal lesion formation induced experimentally by EtOH, HCl, NaOH, and boiling water. The mechanism of action has been suggested to involve inhibition of pepsin activity in gastric juice by precipitating pepsin in the form of a complex and inactivating pepsinogen.

Technology Process of Ecabet sodium

There total 3 articles about Ecabet sodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

12-sulfodehydroabietic acid disodium salt (86408-71-1,86408-72-2) → ecabet sodium (86408-72-2)

Guidance literature:

With hydrogenchloride; In water; pH 3.7;

DOI:10.1248/cpb.33.1472

Reference yield: 90.0%

12-sulfodehydroabietic acid (33159-27-2) → 12-sulfodehydroabietic acid disodium salt (86408-71-1,86408-72-2)

Guidance literature:

With sodium hydroxide; In water;

DOI:10.1248/cpb.33.1472

Reference yield: 87.5%

12-sulfodehydroabietic acid (33159-27-2) → ecabet sodium (86408-72-2)

Guidance literature:

With sodium 2-ethylhexanoic acid; In water; Reagent/catalyst; Solvent; Heating;

upstream raw materials:

12-sulfodehydroabietic acid disodium salt

12-sulfodehydroabietic acid

Downstream raw materials:

(1R,4aS,10aR)-7-Isopropyl-1,4a-dimethyl-6-sulfo-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid; compound with 1-(2-dimethylamino-ethyl)-4-phenyl-pyrrolidin-2-one

12-sulfodehydroabietic acid calcium salt

(1R,4aS,10aR)-6-(1-Carboxy-2-phenyl-ethylsulfamoyl)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid

(1R,4aS,10aR)-6-(4-Carboxy-phenylsulfamoyl)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid

Refernces

• 1、 Wada,Kodato,Kawamori,Morikawa,Nakai,Takeda,Saito,Onoda,Tamaki. "Antiulcer activity of dehydroabietic acid derivatives". . p. 1472 - 1487. Retrieved 2007/10/02.