Buccastem

Base Information

• Chemical Name: Buccastem
• CAS No.: 84-02-6
• Molecular Formula: C20H24ClN3S•2C4H4O4
• Molecular Weight: 606.096
• Hs Code.: 2934302300
• European Community (EC) Number: 201-511-3
• NSC Number: 748866,167375
• NCI Thesaurus Code: C775
• RXCUI: 8706
• ChEMBL ID: CHEMBL1200587
• Mol file: 84-02-6.mol

Synonyms:Compazine;Edisylate Salt, Prochlorperazine;Edisylate, Prochlorperazine;Maleate, Prochlorperazine;Prochlorperazine;Prochlorperazine Edisylate;Prochlorperazine Edisylate Salt;Prochlorperazine Maleate;Salt, Prochlorperazine Edisylate

Chemical Property of Buccastem

Chemical Property:

• Appearance/Colour: Off-White Powder
• Vapor Pressure: 6.76E-32mmHg at 25°C
• Melting Point: 228ºC
• Boiling Point: 524.8 °C at 760 mmHg
• PKA: pKa 8.1(H2O,t =24±1) (Uncertain)
• Flash Point: 271.2 °C
• PSA: 184.22000
• LogP: 3.94460
• Storage Temp.: Store at RT
• Solubility.: Very slightly soluble in water and in ethanol (96 per cent).
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 6
• Exact Mass: 489.1489053
• Heavy Atom Count: 33
• Complexity: 548

Purity/Quality:

98%,99%, ^*data from raw suppliers

Prochlorperazine dimaleate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl.C(=CC(=O)O)C(=O)O
• Isomeric SMILES: CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl.C(=C\C(=O)O)\C(=O)O
• Description: Prochlorperazine maleate (84-02-6) inhibits dynamin and clathrin-mediated endocytosis (CME) with an IC50=5.8 μM for CME.1?Increases tumor cell antigen presentation enhancing the efficacy of anti-tumor mAbs.2?A clinically useful antipsychotic agent3?with antimigraine4?and antiemetic activity5.

Technology Process of Buccastem

There total 1 articles about Buccastem which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ prochlorperazine dimaleate (84-02-6)

Guidance literature:

aus 3-Chlor-10-(3-(di-N-chlorethyl)aminopropyl)-phenthiazin*HCl;

Reference yield:

prochlorperazine dimaleate (84-02-6) → 2-chloro-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine 5,5-dioxide

Guidance literature:

prochlorperazine dimaleate; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 120h;

With triphenylphosphine; In acetonitrile; for 72h; Reflux;