Mitoguazone

Base Information

• Chemical Name: Mitoguazone
• CAS No.: 459-86-9
• Molecular Formula: C₅H₁₂N₈
• Molecular Weight: 184.204
• European Community (EC) Number: 610-278-0
• UNII: OD5Q0L447W
• Wikipedia: Mitoguazone
• NCI Thesaurus Code: C661
• Metabolomics Workbench ID: 153850
• ChEMBL ID: CHEMBL216913
• Mol file: 459-86-9.mol

Synonyms:Methyl gag;Methyl-gag;Methylgag;Methylglyoxal Bis(guanylhydrazone);MGBG;Mitoguazone;NSC 32946;NSC-32946;NSC32946

Chemical Property of Mitoguazone

Chemical Property:

• Vapor Pressure: 7.99E-08mmHg at 25°C
• Melting Point: 225 °C (decomp)
• Refractive Index: 1.692
• Boiling Point: 436.6 °C at 760 mmHg
• PKA: 7.63, 9.05(at 25℃)
• Flash Point: 217.8 °C
• PSA: 148.52000
• Density: 1.55 g/cm³
• LogP: 0.69610
• XLogP3: -2.2
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 184.11849242
• Heavy Atom Count: 13
• Complexity: 264

Purity/Quality:

98%,99%, ^*data from raw suppliers

Mitoguazone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=NN=C(N)N)C=NN=C(N)N
• Isomeric SMILES: C/C(=N\N=C(N)N)/C=N/N=C(N)N
• Recent ClinicalTrials: A Study of Mitoguazone Dihydrochloride in Patients With AIDS-Related Non-Hodgkin's Lymphoma
• Uses: Mitoguazone has therapeutic applications as a cytotoxic agent.

Technology Process of Mitoguazone

There total 3 articles about Mitoguazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

aminoguanidine bicarbonate (2582-30-1) + 2-oxopropanal (78-98-8) → Mitoguazone (459-86-9)

Guidance literature:

With sulfuric acid;

DOI:10.1021/jm00340a020

Reference yield:

→ mitoguazone (459-86-9)

Guidance literature:

Reference yield:

→ Mitoguazone (459-86-9)

Guidance literature:

Dihydrochlorid;

upstream raw materials:

aminoguanidine bicarbonate

2-oxopropanal

Refernces

• 1、 -. "Process of preparing 2,2'-(1-methyl-1,2-ethanediylidene) bis[hydrazinecarboximidamide]". . . Retrieved 2008/06/13.