Trimethyltin hydroxide

Base Information

• Chemical Name: Trimethyltin hydroxide
• CAS No.: 56-24-6
• Molecular Formula: C3H10 O Sn
• Molecular Weight: 180.822
• European Community (EC) Number: 677-697-9
• UNII: 10ALT8DJ2V
• DSSTox Substance ID: DTXSID9032240
• Mol file: 56-24-6.mol

Synonyms:trimethyltin hydroxide

Chemical Property of Trimethyltin hydroxide

Chemical Property:

• Melting Point: 118°C
• Boiling Point: 80°C
• PKA: 6.36±0.70(Predicted)
• Flash Point: °C
• PSA: 20.23000
• Density: g/cm³
• LogP: 0.81360
• Sensitive.: Moisture Sensitive
• Water Solubility.: Soluble in water.
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 182.983193
• Heavy Atom Count: 5
• Complexity: 11.6

Purity/Quality:

98%,99%, ^*data from raw suppliers

TrimethyltinHydroxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): A poison. TWA 0.1 mg(Sn)/m³; STEL 0.2 mg(Sn)/m³ (skin).
• Hazard Codes: T+:Very toxic
• Statements: 20/21/22
• Safety Statements: 22-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Sn](C)C.O
• Uses: Drug. Trimethyltin hydroxide is used in the synthesis of modified thymines, which is useful as inhibitors of RNase A. It is also used in the preparation of ketoheterocycle inhibitors of fatty acid amide inhibitors. It reacts with 2,2-disubstituted benzothiazolines to form trialkyltin derivatives of sulphur containing Schiff base complexes.

Technology Process of Trimethyltin hydroxide

There total 43 articles about Trimethyltin hydroxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(CH3)3SnCH2C6H4-m-Cl (27640-06-8) → trimethyltin(IV) hydroxide (56-24-6)

Guidance literature:

With sodium hydroxide; In ethanol; water; byproducts: m-chlorotoluene; refluxing for 52 h;;

Reference yield: 63.0%

2,6-dichloro-1,4-benzoquinone (697-91-6) + hexamethyldistannane (661-69-8) → C6Cl2H2(OSn(CH3)3)2 (76279-09-9) + trimethyltin(IV) hydroxide (56-24-6)

Guidance literature:

In benzene; keeping at room temp. (N2) for 4 d; various yields in various conditions; evapn.; elem. anal.;

Reference yield: 47.0%

tris(trimethylstannyl)stibine (7029-29-0) → bis(trimethyltin)oxide (1692-18-8) + tetrakis(trimethylstannyl)distibane (68354-51-8) + trimethyltin(IV) hydroxide (56-24-6)

Guidance literature:

With oxygen; In neat (no solvent); stibane left in air for 3 d; suspending in Ar-satd. acetone, decanting, recrystn. of red residue from toluene (2nd and 3rd product isolated from acetone suspn.); elem. anal.;

upstream raw materials:

trimethyl(trimethylstannyl)silane

trimethyltin bromide

(pentafluorophenyl)trimethyltin

2-(trimethylstannyl)-1-methylimidazole

Downstream raw materials:

tetramethylstannane

Trimethylzinnisocyanat

trimethyltin α-phenyl-α-oxoacetate

(CH₃)3Sn(C₁₇H₁₁ClNO₂S)*H₂O

Refernces

• 1、 Seyferth et al.. "-". . p. 1954. Retrieved 1969.
• 2、 Kriegsmann et al.. "-". . p. 283,288. Retrieved 1962.
• 3、 Nath, Mala,Jairath, Ruchi,Eng, George,Song, Xueqing,Kumar, Ashok. "New organotin(IV) ascorbates: Synthesis, spectral characterization, biological and potentiometric studies". . p. 77 - 86. Retrieved 2007/10/03.
• 4、 Pandolfo, Luciano,Paiaro, Gastone. "Reactions of Carbon Suboxide with Hydrides". . p. 531 - 534. Retrieved 2007/10/02.