Multi-step reaction with 7 steps
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / 16 h / 70 °C / 2585.81 Torr
2: iodine; potassium hydroxide / N,N-dimethyl-formamide / 4 h / 20 °C
3: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C
4: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C
5: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 40 °C
6: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 16 h / 70 °C / Inert atmosphere
7: boron tribromide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0); water; iodine; boron tribromide; sodium carbonate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
6: |Suzuki Coupling;