6-BROMO-4-FLUORO-1H-INDAZOLE

Base Information

• Chemical Name: 6-BROMO-4-FLUORO-1H-INDAZOLE
• CAS No.: 885520-23-0
• Molecular Formula: C7H4BrFN2
• Molecular Weight: 215.025
• Hs Code.: 2933990090
• Mol file: 885520-23-0.mol

Synonyms:6-bromo-4-fluoro-1H-indazole;

Chemical Property of 6-BROMO-4-FLUORO-1H-INDAZOLE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.693
• Boiling Point: 331.275 °C at 760 mmHg
• PKA: 12.00±0.40(Predicted)
• Flash Point: 154.15 °C
• PSA: 28.68000
• Density: 1.862 g/cm³
• LogP: 2.46450
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Bromo-4-fluoro-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMO-4-FLUORO-1H-INDAZOLE

There total 5 articles about 6-BROMO-4-FLUORO-1H-INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-bromo-2,6-difluorobenzaldehyde (537013-51-7) → 6-bromo-4-fluoro-1H-indazole (885520-23-0)

Guidance literature:

With hydrazine hydrate; In ethylene glycol; at 95 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2016.10.003

Reference yield: 51.0%

5-bromo-3-fluoro-2-methyl-phenylamine (886761-86-0) → 6-bromo-4-fluoro-1H-indazole (885520-23-0)

Guidance literature:

5-bromo-3-fluoro-2-methyl-phenylamine; With potassium acetate; acetic anhydride; In chloroform; at 60 - 65 ℃; for 0.5h;

With potassium acetate; isopentyl nitrite; In chloroform; at 60 ℃; for 15h;

With hydrogenchloride; In methanol; water; at 60 ℃; for 2h;

DOI:10.1021/acs.jmedchem.7b00418

Reference yield: 41.0%

6-bromo-4-fluoro-1H-indazol-3-amine (1227912-19-7) → 6-bromo-4-fluoro-1H-indazole (885520-23-0)

Guidance literature:

With hypophosphorous acid; isopentyl nitrite; In ethanol; at 0 - 20 ℃;

upstream raw materials:

4-bromo-2,6-difluorobenzonitrile

6-bromo-4-fluoro-1H-indazol-3-amine

4-bromo-2,6-difluorobenzaldehyde

5-bromo-3-fluoro-2-methyl-phenylamine

Downstream raw materials:

(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-3-iodo-1H-indazol-6-yl)(3-methoxyazetidin-1-yl)methanone

methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-6-(3-methoxyazetidine-1-carbonyl)-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-6-(3-methoxyazetidine-1-carbonyl)-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoate

4-(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-6-(3-methoxyazetidine-1-carbonyl)-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid

Refernces

• 1、 -. "Compound with dual inhibitory activity TDO, IDOO1 and application of compound for treating neurodegenerative disease (by machine translation)". Paragraph 0149; 0241-0244. . Retrieved 2020/10/06.
• 2、 -. "Inhibiting effect of trisubstituted pyrimidine derivative on protein kinase". Paragraph 0020-0021; 0024-0025. . Retrieved 2019/09/14.