Technology Process of (S)-benzyl [2-(2-(2-(1,3-dioxoisoindolin-2-yl)ethyl)-1,3-dioxan-2-yl)-1-phenylethyl]carbamate
There total 7 articles about (S)-benzyl [2-(2-(2-(1,3-dioxoisoindolin-2-yl)ethyl)-1,3-dioxan-2-yl)-1-phenylethyl]carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid; trimethyl orthoformate;
In
dichloromethane;
at 20 ℃;
for 18h;
DOI:10.1002/ejoc.201200919
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide / methanol; water / 16 h / 20 °C
2.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h / 20 °C
2.2: 18 h / 20 °C
3.1: tetrahydrofuran / 0.33 h / 0 °C
4.1: N-benzyl-trimethylammonium hydroxide / ethyl acetate / 16 h / Reflux
5.1: toluene-4-sulfonic acid; trimethyl orthoformate / dichloromethane / 18 h / 20 °C
With
N-benzyl-trimethylammonium hydroxide; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; sodium hydroxide; trimethyl orthoformate;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
DOI:10.1002/ejoc.201200919
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 144 h / 3102.97 Torr
2.1: sodium carbonate / dichloromethane; water / 16 h / 20 °C
3.1: sodium hydroxide / methanol; water / 16 h / 20 °C
4.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h / 20 °C
4.2: 18 h / 20 °C
5.1: tetrahydrofuran / 0.33 h / 0 °C
6.1: N-benzyl-trimethylammonium hydroxide / ethyl acetate / 16 h / Reflux
7.1: toluene-4-sulfonic acid; trimethyl orthoformate / dichloromethane / 18 h / 20 °C
With
10 wt% Pd(OH)2 on carbon; hydrogen; N-benzyl-trimethylammonium hydroxide; sodium carbonate; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; sodium hydroxide; trimethyl orthoformate;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
DOI:10.1002/ejoc.201200919