Flumazenil

Base Information Edit

Chemical Name:Flumazenil
CAS No.:78755-81-4
Molecular Formula:C15H14FN3O3
Molecular Weight:303.293
Hs Code.:2933997500
European Community (EC) Number:616-650-9
NSC Number:759193
UNII:40P7XK9392
DSSTox Substance ID:DTXSID2023064
Nikkaji Number:J23.594F
Wikipedia:Flumazenil
Wikidata:Q421920
NCI Thesaurus Code:C47534
RXCUI:4457
Pharos Ligand ID:9WDBNLW1QLLP
Metabolomics Workbench ID:43419
ChEMBL ID:CHEMBL407
Mol file:78755-81-4.mol

Synonyms:Anexate;Flumazenil;Flumazepil;Lanexat;Ro 15 1788;Ro 15-1788;Ro 151788;Romazicon

Suppliers and Price of Flumazenil

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Flumazenil
10mg
$ 339.00

TRC
Flumazenil
25mg
$ 50.00

TRC
Flumazenil
100mg
$ 100.00

Tocris
Flumazenil ≥99%(HPLC)
10
$ 102.00

Tocris
Flumazenil ≥99%(HPLC)
50
$ 428.00

TCI Chemical
Flumazenil >99.0%(GC)
100mg
$ 234.00

TCI Chemical
Flumazenil >99.0%(GC)
25mg
$ 82.00

Sigma-Aldrich
Flumazenil - CAS 78755-81-4 - Calbiochem
10 mg
$ 92.60

Sigma-Aldrich
Flumazenil - CAS 78755-81-4 - Calbiochem
5059910001
$ 89.30

Sigma-Aldrich
Flumazenil >99% (HPLC), solid
25mg
$ 337.00

Total 175 raw suppliers

Chemical Property of Flumazenil Edit

Chemical Property:

Appearance/Colour:Colourless crystals
Vapor Pressure:3.1E-11mmHg at 25°C
Melting Point:201-203 °C
Refractive Index:1.633
Boiling Point:528 °C at 760 mmHg
PKA:0.86±0.20(Predicted)
Flash Point:273.1 °C
PSA：64.43000
Density:1.39 g/cm³
LogP:1.71160
Storage Temp.:2-8°C
Solubility.:Soluble in DMSO to 25mM
Water Solubility.:128 mg/L
XLogP3:1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:303.10191948
Heavy Atom Count:22
Complexity:461

Purity/Quality:

Above 99% ^*data from raw suppliers

Flumazenil ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-27-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC(=C3)F)C
Recent ClinicalTrials:Reversal of Remimazolam by a Single Dose of Flumazenil
Recent EU Clinical Trials:Cognitive impairment and functional reorganization in multiple sclerosis: The role of GABA and glutamate
Recent NIPH Clinical Trials:Comparison of remimazolam + flumazenil antagonization and propofol on emergence time in patients who undergo awake craniotomy: a randomized comparative study
Description Flumazenil is a benzodiazepine antagonist useful as a fast-acting antidote in the treatment of benzodiazepine intoxication, and in reversing the central sedative effects of benzodiazepines during anesthesia.
Uses Flumazenil is an imidazodiazepine which selectively blocks the central effects of classic benzodiazepines. It is used as benzodiazepine antagonist sedation reversal drug.
Therapeutic Function Benzodiazepine receptor antagonist, Anticonvulsant
Clinical Use Reversal of sedative effects of benzodiazepines in anaesthetic, intensive care, and diagnostic procedures
Drug interactions Potentially hazardous interactions with other drugs None known

Technology Process of Flumazenil

There total 38 articles about Flumazenil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 428507-28-2
(E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester

: 193693-31-1
2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one

: 78755-81-4
flumazenil

Guidance literature:: (E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -35 ℃; for 1.5h;

2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one; With Dimethyl-p-toluidine; In tetrahydrofuran; at -40 - -35 ℃; for 3h;

With acetic acid; In tetrahydrofuran; for 6h; pH=5 - 7; Heating;
DOI:10.1016/S0040-4039(03)00078-9

Reference yield: 61.3%

: 105-56-6
ethyl 2-cyanoacetate

: 193693-31-1
2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one

: 78755-81-4
flumazenil

Guidance literature:: With N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h; Reagent/catalyst; Solvent;