p-CHLOROAMPHETAMINE

Base Information

• Chemical Name: p-CHLOROAMPHETAMINE
• CAS No.: 64-12-0
• Deprecated CAS: 2275-84-5
• Molecular Formula: C9H12 Cl N
• Molecular Weight: 169.654
• NSC Number: 287208
• UNII: 897NVD4A52
• DSSTox Substance ID: DTXSID90897229
• Nikkaji Number: J124.932K
• Wikipedia: Para-Chloroamphetamine
• Wikidata: Q229944
• NCI Thesaurus Code: C28175
• Pharos Ligand ID: W6ZZU9L9ZPJB
• ChEMBL ID: CHEMBL358967
• Mol file: 64-12-0.mol

Synonyms:LY 121860;Ly 123362;LY-121860;Ly-123362;LY121860;Ly123362;p Chloramphetamine;p Chloroamphetamine;p-Chloramphetamine;p-Chloroamphetamine;para Chloroamphetamine;para-Chloroamphetamine;Parachloroamphetamine

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of p-CHLOROAMPHETAMINE

Chemical Property:

• Vapor Pressure: 0.0307mmHg at 25°C
• Boiling Point: 244.2°C at 760 mmHg
• PKA: pKa 9.80 (Uncertain)
• Flash Point: 117°C
• PSA: 26.02000
• Density: 1.096g/cm³
• LogP: 2.93000
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 169.0658271
• Heavy Atom Count: 11
• Complexity: 108

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=C(C=C1)Cl)N

Technology Process of p-CHLOROAMPHETAMINE

There total 10 articles about p-CHLOROAMPHETAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-chloro-4-(2-nitropropenyl)benzene (710-20-3) → p-Chloroamphetamine (64-12-0,2275-84-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 3h; Inert atmosphere; Reflux;

DOI:10.1039/c1ob06251d

Reference yield: 75.0%

1-(4-chlorophenyl)propan-2-one oxime (1454-65-5) → p-Chloroamphetamine (64-12-0,2275-84-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 3h; Heating;

Reference yield:

1-chloro-4-(2-chloro-propyl)-benzene (13663-06-4) → p-Chloroamphetamine (64-12-0,2275-84-5)

Guidance literature:

With ethanol; ammonia; at 160 ℃;

DOI:10.1021/ja01210a032

upstream raw materials:

1-chloro-4-(2-chloro-propyl)-benzene

formamide

1-(4-chlorophenyl)propan-2-one

1-chloro-4-(2-nitropropenyl)benzene

Downstream raw materials:

C₁₂H₁₆ClNO₂

(S)-(+)-1-(4'-chloro)phenyl-2-propanamine

(R)-(-)-1-(4'-chloro)phenyl-2-propanamine

2-Acetamino-1-(4-chlor-phenyl)-propan

Refernces

• 1、 Munoz, Lourdes,Rodriguez, Anna M.,Rosell, Gloria,Bosch, M. Pilar,Guerrero, Angel. "Enzymatic enantiomeric resolution of phenylethylamines structurally related to amphetamine". experimental part. p. 8171 - 8177. Retrieved 2012/01/04.
• 2、 Leclerc,Decker,Schwartz. "Derivatives related to betaxolol with α- and β-adrenergic activities". . p. 1357 - 1367. Retrieved 2007/10/02.