(2R,3S)-3-(2-(4-(4-fluorophenoxy)phenyl)pyrimidin-4-yl)-2,3-dihydroxypropanamide

Base Information

• Chemical Name: (2R,3S)-3-(2-(4-(4-fluorophenoxy)phenyl)pyrimidin-4-yl)-2,3-dihydroxypropanamide
• CAS No.: 1433050-67-9
• Molecular Formula: C₁₉H₁₆FN₃O₄
• Molecular Weight: 369.352
• Mol file: 1433050-67-9.mol

Synonyms:(2R,3S)-3-(2-(4-(4-fluorophenoxy)phenyl)pyrimidin-4-yl)-2,3-dihydroxypropanamide

Chemical Property of (2R,3S)-3-(2-(4-(4-fluorophenoxy)phenyl)pyrimidin-4-yl)-2,3-dihydroxypropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S)-3-(2-(4-(4-fluorophenoxy)phenyl)pyrimidin-4-yl)-2,3-dihydroxypropanamide

There total 9 articles about (2R,3S)-3-(2-(4-(4-fluorophenoxy)phenyl)pyrimidin-4-yl)-2,3-dihydroxypropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H19FN2O5 (1433052-13-1) → (2R,3S)-3-(2-(4-(4-fluorophenoxy)phenyl)pyrimidin-4-yl)-2,3-dihydroxypropanamide (1433050-67-9)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 12h;

Reference yield:

C9H9ClN2O2 (271258-66-3) → (2R,3S)-3-(2-(4-(4-fluorophenoxy)phenyl)pyrimidin-4-yl)-2,3-dihydroxypropanamide (1433050-67-9)

Guidance literature:

Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride / 2 h / 100 °C

2: water; AD-mix α / isopropyl alcohol / 6 h / 20 °C

3: ammonia / methanol / 12 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; AD-mix α; tetrabutyl ammonium fluoride; ammonia; water; In methanol; isopropyl alcohol;

Reference yield:

4-(4-fluorophenoxy)-1-nitrobenzene (2561-25-3) → (2R,3S)-3-(2-(4-(4-fluorophenoxy)phenyl)pyrimidin-4-yl)-2,3-dihydroxypropanamide (1433050-67-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: hydrogen; 5%-palladium/activated carbon / 20 °C

2.1: sulfuric acid; sodium nitrite / water; 1,2-dimethoxyethane / 0.83 h / 0 - 5 °C

2.2: 0 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere

4.1: bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride / 2 h / 100 °C

5.1: water; AD-mix α / isopropyl alcohol / 6 h / 20 °C

6.1: ammonia / methanol / 12 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; AD-mix α; sulfuric acid; 5%-palladium/activated carbon; tetrabutyl ammonium fluoride; ammonia; water; hydrogen; potassium acetate; sodium nitrite; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; isopropyl alcohol;

upstream raw materials:

C₉H₉ClN₂O₂

2-(4-(4-fluorophenoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

C₂₁H₁₉FN₂O₅

4-(4-fluorophenoxy)-1-nitrobenzene

Refernces