Idebenone

Base Information Edit

Chemical Name:Idebenone
CAS No.:58186-27-9
Molecular Formula:C19H30O5
Molecular Weight:338.444
Hs Code.:2933399990
European Community (EC) Number:814-253-7
NSC Number:759228
UNII:HB6PN45W4J
DSSTox Substance ID:DTXSID0040678
Nikkaji Number:J22.706D
Wikipedia:Idebenone
Wikidata:Q4197874
NCI Thesaurus Code:C74158
Pharos Ligand ID:1UY851FM8LZR
Metabolomics Workbench ID:87109
ChEMBL ID:CHEMBL252556
Mol file:58186-27-9.mol

Synonyms:CV 2619;CV-2619;hydroxydecyl ubiquinone;idebenone;noben;Raxone

Suppliers and Price of Idebenone

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Idebenone
10mg
$ 310.00

TRC
Idebenone
1g
$ 920.00

Tocris
Idebenone ≥99%(HPLC)
10
$ 73.00

Tocris
Idebenone ≥99%(HPLC)
50
$ 308.00

TCI Chemical
Idebenone >98.0%(HPLC)(T)
5g
$ 165.00

TCI Chemical
Idebenone >98.0%(HPLC)(T)
25g
$ 496.00

TCI Chemical
Idebenone >98.0%(HPLC)(T)
1g
$ 95.00

SynQuest Laboratories
Idebenone
500 mg
$ 24.00

Sigma-Aldrich
Idebenone analytical standard
10mg
$ 74.80

Sigma-Aldrich
Idebenone ≥98% (HPLC)
25mg
$ 127.00

Total 212 raw suppliers

Chemical Property of Idebenone Edit

Chemical Property:

Appearance/Colour:Yellow-orange crystalline powder
Vapor Pressure:5.67E-12mmHg at 25°C
Melting Point:52-55 °C
Refractive Index:1.502
Boiling Point:497.3 °C at 760 mmHg
PKA:15.20±0.10(Predicted)
Flash Point:170.1 °C
PSA：72.83000
Density:1.08 g/cm³
LogP:3.46230
Storage Temp.:Room temp
Solubility.:Soluble in DMSO (up to 25 mg/ml).
XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:12
Exact Mass:338.20932405
Heavy Atom Count:24
Complexity:502

Purity/Quality:

99%,98%, ^*data from raw suppliers

Idebenone ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=O)C(=C(C1=O)OC)OC)CCCCCCCCCCO
Recent ClinicalTrials:Study to Assess the Safety and Tolerability of Idebenone in the Treatment of Friedreich's Ataxia Patients
Recent EU Clinical Trials:Raxone? treatment for patients with dominant optic atrophy due to OPA1 gene mutation
Recent NIPH Clinical Trials:Multicenter study of therapeutic effects of Idebenone in patients with Leber hereditary optic neuropathy
Description Idebenone is an organic compound belonging to the quinone family, being similar to coenzyme Q-10. It is a kind of drug developed by Takeda Pharmaceutical Company for the treatment of Alzheimer’s disease and some other cognitive defects. However, these have been not very much progress associated with this indication. It is now also used for the treatment of Friedreich’s ataxia with a positive effect on cardiac hypertrophy and neurological function. However, this indication is only approved in Canada, not in Europe and US. It is now under investigation on its efficacy for the treatment of Duchenne muscular dystrophy, Leber’s hereditary optic neuropathy, mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) as well as primary progressive multiple sclerosis. The efficacy of this drug still demands more evidences.
Uses idebenone is an anti-oxidant capable of protecting the skin from a variety of free-radical attacks, including the formation of secondary chemicals that negatively affect skin physiology. It is said to improve intrinsic as well as extrinsic skin damage caused by freeradical formation. Idebenone is a synthetically manufactured form of coenzyme Q10 and has a smaller molecular structure. This allows it to penetrate the skin and apparently the cellular membrane. Clinical studies demonstrate a visible improvement in photodamaged skin, reduced skin roughness and dryness, decreased fine lines and wrinkles, and increased skin hydration. In addition, idebenone helps improve hyperpigmentation because its molecular structure is similar to that of hydroquinone. Although most of the associated benefits are seen primarily in the epidermis, some increase in dermal collagen has also been confirmed. Idebenone has been used for such health-related problems as Alzheimer’s and heart disease.

Technology Process of Idebenone

There total 37 articles about Idebenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%