Amorolfine

Base Information Edit

Chemical Name:Amorolfine
CAS No.:78613-35-1
Molecular Formula:C21H35NO
Molecular Weight:317.515
Hs Code.:
DSSTox Substance ID:DTXSID0046690
Nikkaji Number:J389.118F
Wikipedia:Amorolfine
Wikidata:Q123195
NCI Thesaurus Code:C81332
Metabolomics Workbench ID:52779
ChEMBL ID:CHEMBL489411
Mol file:78613-35-1.mol

Synonyms:amorolfin hydrochloride;amorolfine;amorolfine hydrochloride;Locéryl;Loceryl;Locetar;Odenil;Ro 14-4767-002;Ro-14-4767-002

Suppliers and Price of Amorolfine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Amorolfine
40mg
$ 910.00

AvaChem
Amorolfine
10g
$ 690.00

AvaChem
Amorolfine
1g
$ 179.00

AvaChem
Amorolfine
100mg
$ 49.00

AvaChem
Amorolfine
25mg
$ 39.00

American Custom Chemicals Corporation
AMOROLFINE 95.00%
1G
$ 752.87

Total 87 raw suppliers

Chemical Property of Amorolfine Edit

Chemical Property:

Appearance/Colour:white to off-white crystalline powder
Melting Point:134oC
Boiling Point:407.077 °C at 760 mmHg
PKA:7.33±0.10(Predicted)
Flash Point:119.612 °C
PSA：12.47000
Density:0.925 g/cm³
LogP:4.59990
XLogP3:5.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:317.271864740
Heavy Atom Count:23
Complexity:336

Purity/Quality:

99%, ^*data from raw suppliers

Amorolfine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 20/21/22-36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(C)(C)C1=CC=C(C=C1)CC(C)CN2CC(OC(C2)C)C
Isomeric SMILES:CCC(C)(C)C1=CC=C(C=C1)CC(C)CN2C[C@H](O[C@H](C2)C)C
Recent ClinicalTrials:Mycosis Culture Collection From Dermatological Isolated
Recent EU Clinical Trials:A Randomized, Single-Blinded, Comparative Study of Mycosinate and Curanail in the Treatment of Fungal Nail Infection
Clinical Use Amorolfine is the only drug in this class that is employed clinically in the treatment of human fungal infections. Amorolfine is not currently available in the United States, but it is marketed in Europe and Asia for the topical treatment of dermatophytic infections.

Technology Process of Amorolfine

There total 16 articles about Amorolfine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: C₂₁H₃₃NO₂

: 78613-35-1,288583-04-0,288583-03-9
amorolfine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 30 ℃; Reagent/catalyst; Inert atmosphere;

Reference yield: 91.64%

: 75-85-4
tert-Amyl alcohol

: 922734-43-8
(2R,6S)-2,6-dimethyl-4-(2-methyl-3-phenylpropyl)morpholine hydrochloride

: 78613-35-1,288583-04-0,288583-03-9
amorolfine

Guidance literature:: (2R,6S)-2,6-dimethyl-4-(2-methyl-3-phenylpropyl)morpholine hydrochloride; With sulfuric acid; In dichloromethane; at -10 ℃; for 0.166667h;

tert-Amyl alcohol; In dichloromethane; at -10 - 20 ℃;