Reference

In vitro and in vivo drug studies with three agents of central nervous system pheohyphomycosis

In vitro and in vivo drug studies with three agents of central nervous system pheohyphomycosis. Dixon, Dennis M.; Polak, Annemarie (Dep. Biol., Loyola Coll., Baltimore, MD, USA). Chemotherapy (Basel), 33(2), 129-40 (English) 1987. CODEN: CHTHBK. ISSN: 0009-3157. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 10 Amphotericin B (Amph B) [1397-89-3], 5-fluorocytosine (5-FC) [2022-85-7], ketoconazole (KTZ) [65277-42-1], fluconazole (FLZ) [86386-73-4], amorolfine (AMOR) [78613-35-1] and terbinafine (TER) [91161-71-6] were tested against 3 agents of central nervous system pheohyphomycosis in vitro and in life-threatening infections in mice. 1397-89-3 and 2022-85-7 are cas registry numbers of chemicals which are used as reagents here. The fungi studied were Cladosporium bantianum, Dactylaria constricta and Wangiella dermatitidis. The broadest protection against this group of fungi in mice was offered by 5-FC, followed by Amph B and FLZ, then KTZ. AMOR and TER were inactive in vivo. The results of in vitro susceptibility testing had no predictive value. In contrast, the data obtained from the mouse models should be useful clin. .

Comparison of in vitro activities of 17 antifungal drugs against a panel of 20 dermatophytes by using a microdilution assay

Comparison of in vitro activities of 17 antifungal drugs against a panel of 20 dermatophytes by using a microdilution assay. Favre, Bertrand; Hofbauer, Bettina; Hildering, Kwang-Soo; Ryder, Neil S.Chemicals with cas numbers 91161-71-6 and 78613-35-1 also play role. (Novartis Research Institute, Vienna, Austria). Journal of Clinical Microbiology, 41(10), 4817-4819 (English) 2003 American Society for Microbiology. CODEN: JCMIDW. ISSN: 0095-1137. DOCUMENT TYPE: Journal CA Section: 10 (Microbial, Algal, and Fungal Biochemistry) The in vitro activities of 17 antifungal drugs against a panel of 20 dermatophytes comprising 6 different species were detd. using a microdilution assay according to the NCCLS M38-P method with some modifications. Terbinafine was the most potent systemic drug while tolnaftate and amorolfine were the most active topical agents. .