Metacycline hydrochloride

Base Information

• Chemical Name: Metacycline hydrochloride
• CAS No.: 3963-95-9
• Molecular Formula: C22H23ClN2O8
• Molecular Weight: 478.886
• Hs Code.: 29413020
• Mol file: 3963-95-9.mol

Synonyms:2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-,monohydrochloride (8CI);2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-,monohydrochloride, [4S-(4a,4aa,5a,5aa,12aa)]-;6-Demethyl-6-deoxy-5-hydroxy-6-methylenetetracycline hydrochloride;6-Demethyl-6-deoxy-6-methyleneoxytetracycline monohydrochloride;6-Methylene-5-hydroxytetracycline hydrochloride;6-Methyleneoxytetracyclinehydrochloride;Adriamicina;Ciclobiotic;Germiciclin;Londomycin;Metacyclinhydrochloride;Metadomus;Methacycline monohydrochloride;Metilenbiotic;Optimycin;Physiomycine;Rindex;

Chemical Property of Metacycline hydrochloride

Chemical Property:

• Appearance/Colour: yellow crystalline powder
• Vapor Pressure: 5.4E-28mmHg at 25°C
• Boiling Point: 813.8 °C at 760 mmHg
• Flash Point: 445.9 °C
• PSA: 181.62000
• LogP: 1.06440
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated), Water (Slightly

Purity/Quality:

98%min ^*data from raw suppliers

Methacycline HCl ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25-22

MSDS Files:

SDS file from LookChem

Useful:

• Description: Methacycline is a tetracycline-class antibiotic that is active against a wide range of Gram-positive and Gram-negative organisms. It is readily absorbed from the gastrointestinal tract and reaches a maximum concentration at about the fourth hour, declining to a negligible amount in about 24 hours. It is more active than tetracycline against a number of bacteria.
• Uses: Broad spectrum, semisynthetic antibiotic related to Tetracycline. Antibacterial. analgesic, narcotic antagonist Methacycline hydrochloride is a salt prepared from methacycline taking advantage of the basic dimethylamino group which protonates and readily forms a salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, methacycline hydrochloride shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis. A broad spectrum, anti bacterial, semisynthetic antibiotic related to Tetracycline
• Therapeutic Function: Antibiotic

Technology Process of Metacycline hydrochloride

There total 1 articles about Metacycline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ methacycline hydrochloride (3963-95-9)

Guidance literature:

Reference yield: 43.0%

methacycline hydrochloride (3963-95-9) + C10H16BO3 → [4S-(4α,12aα)]-4-(dimethylamino)-6-(4-tert-butylbenzylidene)-3,5,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxamide

Guidance literature:

With copper dichloride; In methanol; Heating;

DOI:10.1021/jo030047d

Reference yield: 41.0%

methacycline hydrochloride (3963-95-9) → doxycycline (564-25-0,10597-92-9,7164-70-7,7264-10-0) + 6-epidoxycycline (3219-99-6,10597-92-9,7164-70-7,7264-10-0)

Guidance literature:

With hydrogen; closo-3,3-(η²,η³-C7H7CH2)-3,1,2-RhC2B9H11; In methanol; at 43 ℃; for 4h; under 76000 Torr;

DOI:10.1016/S0040-4039(00)60321-0

Downstream raw materials:

13-(3-chloropropylthio)-5-hydroxy-6-α-deoxytetracycline

doxycycline

6-epidoxycycline

13-(benzylthio)-5-hydroxy-6-α-deoxytetracycline

Refernces