CAS No.3963-95-9,Metacycline hydrochloride Suppliers

Detail of "3963-95-9"

CAS Number:

3963-95-9

Name:

Metacycline hydrochloride

Molecular Structure:

Formula:

C₂₂H₂₃ClN₂O₈

Molecular Weight:

478.88

Deleted CAS:

101813-12-1,2507-30-4,60080-37-7,857212-11-4

Synonyms:

2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-,monohydrochloride (8CI);2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-,monohydrochloride, [4S-(4a,4aa,5a,5aa,12aa)]-;6-Demethyl-6-deoxy-5-hydroxy-6-methylenetetracycline hydrochloride;6-Demethyl-6-deoxy-6-methyleneoxytetracycline monohydrochloride;6-Methylene-5-hydroxytetracycline hydrochloride;6-Methyleneoxytetracyclinehydrochloride;Adriamicina;Ciclobiotic;Germiciclin;Londomycin;Metacyclinhydrochloride;Metadomus;Methacycline monohydrochloride;Metilenbiotic;Optimycin;Physiomycine;Rindex;

EINECS:

223-568-3

Boiling Point:

813.8 °C at 760 mmHg

Flash Point:

445.9 °C

Appearance:

yellow crystalline powder

Safety:

24/25-22 Details

Reference

A high performance liquid chromatographic system for the analysis of tetracycline drug standards, analogs, degradation products and other impurities: A high performance liquid chromatographic system for the analysis of tetracycline drug standards, analogs, degradation products and other impurities. Mack, George D.; Ashworth, Raymond B. (Food Drug Adm., Baltimore, Md., USA). J. Chromatogr. Sci., 16(3), 93-101 (English) 1978. CODEN: JCHSBZ. ISSN: 0021-9665. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Eight tetracycline stds.: tetracycline-HCl [64-75-5], chlortetracycline-HCl [64-72-2], rolitetracycline-HCl [14867-21-1], oxytetracycline [79-57-2], minocycline-HCl [13614-98-7], doxycyclinehyclate [24390-14-5], demeclocycline-HCl [64-73-3], and methacycline-HCl [3963-95-9] and 2 tetracycline epimers, epitetracycline-HCl [23313-80-6], epianhydrotetracycline-HCl [43168-49-6], and anhydrotetracycline-HCl [13803-65-1] were analyzed by high-performance liq. chromatog.(HPLC). The HPLC system employed an octadecylsilane reverse-phase column and an isopropanol-diethanolamine-phosphate-ammonium EDTA-water mobile phase. This system produced at least partial resolution of all 8 compds. and many of their degrdn. products.

Temperature and concentration dependent partitioning of three tetracyclines between phosphate buffers and octanol: Temperature and concentration dependent partitioning of three tetracyclines between phosphate buffers and octanol. Cooke, D. T.; Gonda, I. (Dep. Pharm., Univ. Aston, Birmingham, Engl.). J. Pharm. Pharmacol., 29(3), 190-1 (English) 1977. CODEN: JPPMAB. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Methacycline-HCl (I) [3963-95-9], doxycycline-HCl (II) [10592-13-9], and tetracycline-HCl (III) [64-75-5] were dissolved in octanol [111-87-5]-satd. phosphate buffer, pH 7.5 at 25.degree., and the solns. were shaken with buffer-satd. octanol at the test temp. for 2 h; spectrophotometric anal. of II and III at 274 nm and of I at 282 nm showed that the apparent partition coeffs. (P) of I, II, and III decreased with increasing temp. (25 to 37.degree.) and/or decreasing drug concn. Thus the P values of tetracycline and its analogs should be detd. under conditions closely resembling the biol. activity studied.

Detail of "3963-95-9"

Metacycline hydrochloride

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CAS No.3963-95-9 Metacycline hydrochloride

CAS No.3963-95-9 Metacycline hydrochloride

CAS No.3963-95-9 Metacycline hydrochloride

CAS No.3963-95-9 Metacycline hydrochloride

CAS No.3963-95-9 Metacycline hydrochloride

CAS No.3963-95-9 Metacycline hydrochloride

CAS No.3963-95-9 Metacycline hydrochloride

CAS No.3963-95-9 Metacycline hydrochloride

CAS No.3963-95-9 Metacycline hydrochloride

CAS No.3963-95-9 Metacycline hydrochloride

CAS No.3963-95-9 Metacycline hydrochloride

CAS No.3963-95-9 Metacycline hydrochloride

CAS No.3963-95-9 Metacycline hydrochloride

CAS No.3963-95-9 Metacycline hydrochloride

CAS No.3963-95-9 Metacycline hydrochloride

CAS No.3963-95-9 Metacycline hydrochloride

CAS No.3963-95-9 Metacycline hydrochloride

Reference