Carmellose sodium

Base Information

• Chemical Name: Carmellose sodium
• CAS No.: 9004-32-4
• Deprecated CAS: 117385-93-0,12624-09-8,198084-97-8,37231-14-4,37231-15-5,50642-44-9,54018-17-6,55607-96-0,73699-63-5,80296-93-1,81209-86-1,82197-79-3,9045-95-8,9085-26-1,247080-55-3,404943-62-0,454679-81-3,64103-90-8,654655-39-7,1012064-31-1,1262215-38-2,147881-80-9,854036-84-3,1296213-64-3,1422717-46-1,1428980-42-0,1610028-94-8,1610029-04-3,2014388-59-9,2072854-79-4,2131127-75-6,2228913-23-1,2229957-39-3,2260925-91-3,2416156-06-2,2459461-90-4,2492491-76-4,2715109-01-4
• Molecular Formula: C2H4O3.xNa.xUnspecified
• Molecular Weight: 262.19000
• Hs Code.: 39123100
• European Community (EC) Number: 618-378-6,629-739-2
• NCI Thesaurus Code: C80923,C83596
• RXCUI: 491498,1310573,1371909,1653793,2257286,2475182,2565686,2584311,2625171,2632123
• Mol file: 9004-32-4.mol

Synonyms:Aquacel;Aquaplast;Carboxymethyl Cellulose;Carboxymethylcellulose;Carboxymethylcellulose Sodium;Carboxymethylcellulose, Sodium;carmellose sodium;Cellolax;Cellulose, Carboxymethyl;Cethylose;Croscarmellose Sodium;Polycell;Ruspol;Sodium Carboxymethylcellulose;Sodium, Carboxymethylcellulose;Sodium, Carmellose;Sodium, Croscarmellose

Chemical Property of Carmellose sodium

Chemical Property:

• Appearance/Colour: POWDER
• Vapor Pressure: 2.59E-13mmHg at 25°C
• Melting Point: 274 °C (dec.)
• Boiling Point: 527.1°C at 760 mmHg
• PKA: 4.30(at 25℃)
• Flash Point: 286.7°C
• PSA: 158.35000
• Density: 1,6 g/cm3
• LogP: -4.62260
• Storage Temp.: room temp
• Solubility.: H2O: 20 mg/mL, soluble
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 263.07428675
• Heavy Atom Count: 17
• Complexity: 169

Purity/Quality:

99%, ^*data from raw suppliers

Carboxymethyl Cellulose Sodium n(=:)1050 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R40:有限证据表明其致癌作用
• Hazard Codes: R40:有限证据表明其致癌作用
• Statements: 40
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Biological Agents -> Polysaccharides
• Canonical SMILES: CC(=O)O.C(C(C(C(C(C=O)O)O)O)O)O.[Na]
• Recent ClinicalTrials: Dry Eye Disease Study With Brimonidine
• Recent EU Clinical Trials: ANTIBIOTICS VERSUS PLACEBO FOR ACUTE BACTERIAL CONJUNCTIVITIS IN CHILDREN: A RANDOMISED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL
• Development and History: Sodium carboxymethyl cellulose (CMC) was developed in Germany during World War I as a potential substitute for gelatin. However, technical challenges and high production costs delayed its full-scale commercialization at that time.
• Solubility and Tolerance to Salt: CMC, being hydrophilic, can be salted out of solution with alkali metal salts. However, it is more tolerant to various types and concentrations of salt compared to other hydrocolloids like carrageenan, alginates, or pectin, which are sensitive to specific salts, such as calcium.
• Rheological Properties: Upon complete dissolution, CMC exhibits several useful rheological properties, making it valuable in various applications. It stabilizes and thickens variegated sauces and ribbon ties used in ice cream preparations. It also interacts with bakery ingredients to enhance functional performance.
• Effect on Glucose Metabolism and Lipid Homeostasis: Tadalafil does not significantly affect lipid homeostasis or body composition, as demonstrated by studies showing no change in body mass index (BMI) or adipose tissue levels.
• Oral Drug Delivery: CMC, as a polyanionic biopolymer, is widely used in oral drug delivery systems. Its high pH sensitivity makes it suitable for site-specific drug delivery applications.
• Biodegradability and Non-Toxicity: CMC is a derivative of natural cellulose, making it biodegradable, flexible, and non-toxic. It is known for its ability to form membranes with good barrier function and amphiphilicity.
• Improvement of Film Properties: CMC, when combined with cassava starch (CS), improves the physical and chemical properties of edible films. This combination enhances membrane formation, barrier function, and flexibility, making it suitable for food packaging applications. Studies have shown that CS and CMC blend films can prolong the shelf life of perishable food items like bananas by incorporating lactic acid bacteria.