Technology Process of 1-ethyl-4-(3-fluorobenzyl)piperidine
There total 5 articles about 1-ethyl-4-(3-fluorobenzyl)piperidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethyl bromide; 4-(3-fluorobenzyl)piperidine;
With
potassium carbonate;
In
acetonitrile;
for 20h;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 4 h / 160 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h
2.2: 21.5 h / 20 °C
3.1: hydrogen / acetic acid; industrial methylated spirit / 2 h / Inert atmosphere
4.1: potassium carbonate / acetonitrile / 20 h
With
hydrogen; sodium hydride; potassium carbonate;
In
tetrahydrofuran; industrial methylated spirit; acetic acid; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h
1.2: 21.5 h / 20 °C
2.1: hydrogen / acetic acid; industrial methylated spirit / 2 h / Inert atmosphere
3.1: potassium carbonate / acetonitrile / 20 h
With
hydrogen; sodium hydride; potassium carbonate;
In
tetrahydrofuran; industrial methylated spirit; acetic acid; acetonitrile; mineral oil;
