Technology Process of 2-(1-ethylpiperidine-4-ylmethyl)-4-fluorobenzenesulfonyl chloride
There total 6 articles about 2-(1-ethylpiperidine-4-ylmethyl)-4-fluorobenzenesulfonyl chloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
chlorosulfonic acid;
In
1,2-dichloro-ethane;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate / acetonitrile / 20 h
2: chlorosulfonic acid / 1,2-dichloro-ethane / 2 h / 20 °C
With
chlorosulfonic acid; potassium carbonate;
In
1,2-dichloro-ethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 4 h / 160 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h
2.2: 21.5 h / 20 °C
3.1: hydrogen / acetic acid; industrial methylated spirit / 2 h / Inert atmosphere
4.1: potassium carbonate / acetonitrile / 20 h
5.1: chlorosulfonic acid / 1,2-dichloro-ethane / 2 h / 20 °C
With
chlorosulfonic acid; hydrogen; sodium hydride; potassium carbonate;
In
tetrahydrofuran; industrial methylated spirit; acetic acid; 1,2-dichloro-ethane; acetonitrile; mineral oil;
