KANAMYCIN

Base Information

• Chemical Name: KANAMYCIN
• CAS No.: 8063-07-8
• Molecular Formula: C18H36N4O11
• Molecular Weight: 484.5
• Hs Code.: 29419000
• Mol file: 8063-07-8.mol

Synonyms:(1S,2R,3R,4S,6R)-4,6-diamino-3-[(6-amino-6-deoxy-a-D-glucopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-a-D-glucopyranoside;(1S,2R,3R,4S,6R)-4,6-Diamino-3-[(6-amino-6-deoxy-α-D-glucopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-α-D-glucopyranoside;Cantrex;Cristalomicina;Kanacedin;

Chemical Property of KANAMYCIN

Chemical Property:

• Appearance/Colour: solid
• Vapor Pressure: 2.47E-30mmHg at 25°C
• Refractive Index: 1.669
• Boiling Point: 809.5 °C at 760 mmHg
• Flash Point: 443.4 °C
• PSA: 282.61000
• Density: 1.62 g/cm³
• LogP: -4.49020
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Kanamycin,860u/mg ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 61
• Safety Statements: 36/37/39-45-53

MSDS Files:

SDS file from LookChem

Useful:

• Description: Kanamycin A belongs to the family on aminoglycoside antibiotics which consist of two or more aminosugars linked by glycosidic bonds to an aminocyclitol ring. It was isolated in Japan from Streptomyces kanamyceticus. Clinically, kanamycin is used as a sulfate. Currently, kanamycin is only rarely used; its main place is for the treatment of tuberculosis caused by multidrug-resistant Myobacterium tuberculosis strains .
• Indications: Kanamycin A is similar to streptomycin and neomycines and has a broad spectrum of antimicrobial action. It is active with respect to most Gram-positive as well as Gram-negative microorganisms (staphylococci, gastric bacilli, rabbit fever, Fridlender’s bacillus, proteus, shigella, salmonella). It is used for treating sepsis, meningitis, osteomyelitis, periotonitis, pneumonia, pyelonephritis, pyelocystitis, infected wounds, and post-operational purulent complications caused by microorganisms sensitive to the drug. Synonyms of this drug are karmycin, kamaxin, resistomycin, and many others.
• Therapeutic Function: Antibacterial
• Drug interactions: All aminoglycosides are partially inactivated by high concentrations of any of the penicillins. In vitro, the penicillins inactivate kanamycin to about the same degree as gentamicin and tobramycin, but this occurs less readily with amikacin. Studies with gentamicin and amikacin have shown that heparin reversibly inhibits aminoglycoside activity in a dose-dependent way. This may also apply to kanamycin. Specimens for kanamycin measurements should not be obtained in heparinized tubes. Kanamycin excretion is not affected by probenecid.