Triethylamine hydrochloride

Base Information

• Chemical Name: Triethylamine hydrochloride
• CAS No.: 554-68-7
• Molecular Formula: C6H16ClN
• Molecular Weight: 137.653
• Hs Code.: 29211910
• European Community (EC) Number: 209-067-2
• NSC Number: 30600
• UNII: 0NX3818GCW
• DSSTox Substance ID: DTXSID8060292
• Wikidata: Q15647961
• ChEMBL ID: CHEMBL4446875
• Mol file: 554-68-7.mol

Synonyms:triethylamine;triethylamine acetate;triethylamine dinitrate;triethylamine hydrobromide;triethylamine hydrochloride;triethylamine maleate (1:1);triethylamine phosphate;triethylamine phosphate (1:1);triethylamine phosphonate (1:1);triethylamine sulfate;triethylamine sulfate (2:1);triethylamine sulfite (1:1);triethylamine sulfite (2:1);triethylammonium formate

Chemical Property of Triethylamine hydrochloride

Chemical Property:

• Appearance/Colour: White to off-white crystalline powder
• Vapor Pressure: 56.1mmHg at 25°C
• Melting Point: 254-260 °C
• Refractive Index: 1.4530 (estimate)
• Boiling Point: 90.5 °C at 760 mmHg
• Flash Point: 39 °C
• PSA: 3.24000
• Density: 1.07 g/cm³
• LogP: 2.15010
• Storage Temp.: Store below +30°C.
• Sensitive.: Hygroscopic
• Solubility.: 1440 g/L (20°C)
• Water Solubility.: 1440 g/L (20 ºC)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 137.0971272
• Heavy Atom Count: 8
• Complexity: 25.7

Purity/Quality:

99% ^*data from raw suppliers

Triethylamine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-36/37/39-22

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Amines, Aliphatic
• Canonical SMILES: CCN(CC)CC.Cl
• Uses: Triethylamine Hydrochloride is a hydrochloride salt of triethyllamine (T775740). Triethylamine is used as a competing base for the separation of acidic basic and neutral drugs by reverse-phased high-performance liquid chromatography (HPLC). Triethylamine induces visual disturbances (such as foggy vision) in humans, and is also used in industry as a quenching agent in the ozonolysis of alkenes (e.g. (E)-2-Pentene [P227315]). Triethylamine is used in the purification of drugs which are pharmacologically or chemically similar through separation in reverse-phase HPLC (2).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.

Technology Process of Triethylamine hydrochloride

There total 485 articles about Triethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-Nitrophenyl chloroformate (7693-46-1) + polyethylene glycol → PEG(NPC)2 + triethylamine hydrochloride (554-68-7)

Guidance literature:

With triethylamine; In acetonitrile; at 80 ℃; for 8h; Heating / reflux;

Reference yield: 98.5%

triethylamine N-oxide (2687-45-8) + 1-chloro-2,4-dinitro-benzene (97-00-7) → 2,4-Dinitrophenol (51-28-5) + triethylamine hydrochloride (554-68-7)

Guidance literature:

In N,N-dimethyl-formamide; for 24h;

Reference yield: 97.0%

triethylamine (121-44-8) + p-toluenesulfonyl chloride (98-59-9) + 3-Butyn-1-ol (927-74-2) → 3-butyn-1-yl p-toluenesulfonate (23418-85-1) + triethylamine hydrochloride (554-68-7)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 21h;

upstream raw materials:

chloranil

triethylamine

benzene

tetrachloromethane

Downstream raw materials:

chloroethane

diethylamine

tetrabutyl-ammonium chloride

Triethylammonium perchlorate

Refernces

• 1、 Tu, Zhuo-Heng,Zhang, Yi-Yang,Wu, You-Ting,Hu, Xing-Bang. "Self-enhancement of CO reversible absorption accompanied by phase transition in protic chlorocuprate ionic liquids for effective CO separation from N2". . p. 3390 - 3393. Retrieved 2019.
• 2、 Dhanak, Dashyant,Kuroda, Reiko,Reese, Colin B.. "RING-EXPANSION OF A DIHALOGENOCARBENE ADDUCT OF A CYCLOHEPTENE DERIVATIVE AND THE CORRESPONDING RETRO-REACTION". . p. 1827 - 1830. Retrieved 1987.
• 3、 Beattie,Webster. "-". . p. 1730. Retrieved 1961.
• 4、 -. "Method for preparing amine compound by reducing amide compound". Paragraph 0120-0122. . Retrieved 2021/02/10.
• 5、 Uhlig, Nick,Martins, Andrew,Gao, Detian. "Selective DIBAL-H Monoreduction of a Diester Using Continuous Flow Chemistry: From Benchtop to Kilo Lab". supporting information. p. 2326 - 2335. Retrieved 2020/06/08.