Kytril

Base Information Edit

Chemical Name:Kytril
CAS No.:107007-99-8
Molecular Formula:C18H25ClN4O
Molecular Weight:348.876
Hs Code.:29399990
European Community (EC) Number:634-603-0
UNII:318F6L70J8
DSSTox Substance ID:DTXSID7049057
NCI Thesaurus Code:C1353
RXCUI:142149
ChEMBL ID:CHEMBL1900758
Mol file:107007-99-8.mol

Synonyms:1-Methyl-N-(endo-9-Methyl-9-Azabicyclo(3.3.1)non-3-yl)-1H-Indazole-3-Carboxamide;1H-Indazole-3-carboxamide, 1-methyl-N-(9-methyl-9-azabicyclo(3.3.1)non-3-yl;1H-Indazole-3-carboxamide, 1-methyl-N-(9-methyl-9-azabicyclo(3.3.1)non-3-yl)-, endo-;BRL 43694;BRL 43694A;BRL-43694;BRL-43694A;BRL43694;BRL43694A;Granisetron;Granisetron Hydrochloride;Granisetron Monohydrochloride;Hydrochloride, Granisetron;Kytril;Monohydrochloride, Granisetron

Suppliers and Price of Kytril

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Granisetron, Hydrochloride
10mg
$ 312.00

Usbiological
Granisetron hydrochloride
10mg
$ 310.00

TRC
Granisetron hydrochloride
100mg
$ 150.00

Tocris
Granisetron hydrochloride ≥99%(HPLC)
50
$ 318.00

Tocris
Granisetron hydrochloride ≥99%(HPLC)
10
$ 75.00

TCI Chemical
Granisetron Hydrochloride >98.0%(HPLC)(T)
1g
$ 194.00

TCI Chemical
Granisetron Hydrochloride >98.0%(HPLC)(T)
200mg
$ 58.00

Sigma-Aldrich
Granisetron Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material
500mg
$ 106.00

Sigma-Aldrich
Granisetron hydrochloride European Pharmacopoeia (EP) Reference Standard
$ 190.00

Sigma-Aldrich
Granisetron hydrochloride European Pharmacopoeia (EP) Reference Standard
y0000396
$ 190.00

Total 197 raw suppliers

Chemical Property of Kytril Edit

Chemical Property:

Appearance/Colour:white to off-white crystalline solid
Vapor Pressure:0mmHg at 25°C
Melting Point:290-292 °C
Refractive Index:1.69
Boiling Point:532 °C at 760 mmHg
Flash Point:275.6 °C
PSA：50.16000
Density:1.33g/cm3
LogP:3.44920
Storage Temp.:Room temp
Solubility.:H2O: >10mg/mL
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:348.1716891
Heavy Atom Count:24
Complexity:442

Purity/Quality:

98% up ^*data from raw suppliers

Granisetron, Hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn,Xi
Hazard Codes:Xn,Xi
Statements: 22-62-37/38-36/37/38-36
Safety Statements: 26-36-37-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C.Cl
Isomeric SMILES:CN1[C@@H]2CCC[C@H]1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C.Cl
Recent ClinicalTrials:A Randomized Controlled Trial of SP-01 (Granisetron Transdermal Delivery System) in Chemotherapy-induced Nausea and Vomiting
Recent EU Clinical Trials:GRANISETRON TRANSDERMAL SYSTEM (GTDS) IN PREVENTING NAUSEA AND VOMITING INDUCED BY CISPLATIN-BASED CHEMOTHERAPY AND CONCURRENT RADIOTHERAPY FOR HEAD AND NECK CANCER
Recent NIPH Clinical Trials:None
Uses It is the selective antagonist of the 5-serotonin 3 (5-HT3) in peripheral and central nervous system. anticoagulant A specific serotonin (5HT3) receptor antagonist. Used as an antiemetic. Granisetron HCl is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemothera py. Its main effect is to reduce the activity of the vagus nerve. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarini c receptor These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Description Granisetron hydrochloride is the second selective 5HT-3-antagonist approved for the management of nausea and vomiting induced by cancer chemotherapy.Like ondansetron, granisetron hydrochloride is superior to metoclopramide in both efficacy and side effect profile. The compound appears to be effective both as a prophylactic agent and in blocking vomiting once started.
Therapeutic Function Serotonin antagonist

Technology Process of Kytril

There total 2 articles about Kytril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%