Edtmp

Base Information

• Chemical Name: Edtmp
• CAS No.: 1429-50-1
• Deprecated CAS: 54579-31-6,66300-26-3,85497-53-6,103333-76-2,244775-21-1,103333-76-2,244775-21-1,66300-26-3,85497-53-6
• Molecular Formula: C6H20N2O12P4
• Molecular Weight: 436.126
• Hs Code.: HOSPHONIC ACID PRODUCT IDENTIFICATION
• European Community (EC) Number: 215-851-5,244-742-5,263-254-3,239-204-1
• UNII: V4CP8RSX7V
• DSSTox Substance ID: DTXSID3061689
• Nikkaji Number: J56.130D
• Wikipedia: EDTMP
• Wikidata: Q3045881
• NCI Thesaurus Code: C90830
• ChEMBL ID: CHEMBL1208647
• Mol file: 1429-50-1.mol

Synonyms:(68Ga)-EDTMP;(ethylenedinitrilo)-tetramethylenephosphonic acid;(ethylenedinitrilo)-tetramethylenephosphonic acid, ammonium salt;(ethylenedinitrilo)-tetramethylenephosphonic acid, calcium (1:1) salt;(ethylenedinitrilo)-tetramethylenephosphonic acid, calcium (1:2) salt;(ethylenedinitrilo)-tetramethylenephosphonic acid, calcium, sodium (1:1:4) salt;(ethylenedinitrilo)-tetramethylenephosphonic acid, hexasodium salt;(ethylenedinitrilo)-tetramethylenephosphonic acid, octaammonium salt;(ethylenedinitrilo)-tetramethylenephosphonic acid, pentasodium salt;(ethylenedinitrilo)-tetramethylenephosphonic acid, potassium salt;(ethylenedinitrilo)-tetramethylenephosphonic acid, sodium salt;(ethylenedinitrilo)-tetramethylenephosphonic acid, tetrapotassium salt;(ethylenedinitrilo)-tetramethylenephosphonic acid, tetrasodium salt;(ethylenedinitrilo)-tetramethylenephosphonic acid, trisodium salt;68Ga-EDTMP;Dequest 2041;editempa;editempa acid;EDTPO;ethylenediaminetetra(methylenephosphonic)acid;ethylenediaminetetramethylenephosphonate, gallium salt;gallium-68 labeled ethylenediamine tetramethylene phosphonate;N,N,N',N' ethylenediamine tetra(methylenephosphonic acid)

Chemical Property of Edtmp

Chemical Property:

• Vapor Pressure: 2.43E-34mmHg at 25°C
• Melting Point: 247 °C
• Refractive Index: 1.622
• Boiling Point: 878.7 °C at 760 mmHg
• PKA: 0.13±0.10(Predicted)
• Flash Point: 485.2 °C
• PSA: 275.84000
• Density: 1.993 g/cm³
• LogP: -1.86880
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Aqueous Base (Slightly)
• Water Solubility.: 19.6g/L at 20℃
• XLogP3: -11.2
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 11
• Exact Mass: 435.99667207
• Heavy Atom Count: 24
• Complexity: 486

Purity/Quality:

99% ^*data from raw suppliers

Ethylenediaminetetra(methylenephosphonicacid) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Phosphate Compounds
• Canonical SMILES: C(CN(CP(=O)(O)O)CP(=O)(O)O)N(CP(=O)(O)O)CP(=O)(O)O
• Uses: Ethylenediaminetetra(methylenephosphonic acid) is a nitrogenous polyphosphonic acid chelator is able to form complexes with various metal ions.

Technology Process of Edtmp

There total 11 articles about Edtmp which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + ethylenediamine (107-15-3,85404-18-8) → 1,2-ethanediylbistetraphosphonic acid (1429-50-1)

Guidance literature:

ethylenediamine; With hydrogenchloride; phosphonic Acid; In water; for 0.0333333h; Microwave irradiation;

formaldehyd; In water; for 0.166667h; Microwave irradiation;

DOI:10.1080/10426501003724897

Reference yield: 48.2%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + ethylenediamine (107-15-3,85404-18-8) → 1,2-ethanediylbistetraphosphonic acid (1429-50-1) + N-methylethylenediamine-N,N',N'-trimethylenetris(phosphonic acid)

Guidance literature:

ethylenediamine; With phosphorous acid; In water; at 136 ℃; Reflux;

formaldehyd; In water; at 130 - 136 ℃; for 4.33333h;

Reference yield: 36.7%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + ethylenediamine (107-15-3,85404-18-8) → 1,2-ethanediylbistetraphosphonic acid (1429-50-1) + <<(2-aminoethyl)imino>bis(methylene)>biphosphonic acid

Guidance literature:

With hydrogenchloride; phosphoric acid; In water; at 100 ℃; for 3h;

upstream raw materials:

chloromethylphosphonic acid

ethylenediamino tris(methylenephosphonic acid)

formaldehyd

ethylenediamine

Refernces

• 1、 Hassfjell,Hoff,Bruiand,Alstad. "212Pb/212Bi-EDTMP-Synthesis and biodistribution of a novel bone seeking alpha-emitting radiopharmaceutical". . p. 717 - 734. Retrieved 1994.
• 2、 -. "METHOD FOR THE SYNTHESIS OF AMINOALKYLENEPHOSPHONIC ACID". Paragraph 0084. . Retrieved 2014/02/15.
• 3、 Villemin, Didier,Moreau, Bernard,Elbilali, Abdelghani,Didi, Mohamed-Amine,Kaid, Mhamed,Jaffres, Paul-Alain. "Green synthesis of poly(aminomethylenephosphonic) acids". experimental part. p. 2511 - 2519. Retrieved 2011/02/28.